| abstract |
A derivative of a GLP-1 peptide, wherein the peptide has only two Lys residues, namely a first and a second Lys residue, and a maximum of eight amino acid changes compared to GLP-1 (7-37 ) (SEQ ID NO: 3), wherein the derivative comprises two long acting residues fixed to the amino epsilon group of said first and second Lys residues, respectively, through a linker, in which the long acting rest is select between Chem. 15 and Chem. 16: Chem. 15: HOOC- (CH2) x-CO- * Chem. 16: HOOC-C6H4-O- (CH2) and-CO- *, where x is an integer in the range of 10-16 ey is an integer in the range of 8-12; and the linker comprises a first linker element, Chem. 1: ** Formula ** or a pharmaceutically acceptable salt, amide or ester of said derivative. |