http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2625931-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9da537f4ec0129a521ae254ed2b7e11c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2982 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-30 |
| filingDate | 2007-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae61eccd39b1d86716f69c095e4b2f3e |
| publicationDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2625931-T3 |
| titleOfInvention | Process for the preparation of ibuprofen sodium salt of different particle sizes |
| abstract | A controlled average particle size ibuprofen sodium salt production process, a process comprising: A) adding an aqueous solution of sodium hydroxide to a non-boiling solution or suspension of ibuprofen in an inert distillable hydrocarbon solvent aliphatic liquid, said solvent having the ability to distil together with water at a temperature in the range of 50 to 120 ºC, adding the aqueous sodium hydroxide solution at a rate that does not make the resulting reaction mixture boil before it has been completed the addition; B) after completing the addition in A), remove the water distilling solvent and water from the reaction mixture until a suspension of ibuprofen sodium is formed in a liquid phase composed substantially entirely of said solvent; C) causing the temperature of said suspension formed in B) to drop to room temperature and optionally causing the suspension to sit in an inactive state; and D) recovering the ibuprofen sodium salt from said suspension by means of a physical solid-liquid separation procedure; said process being further characterized by the control of the average particle size of the ibuprofen sodium salt that is formed in the process by selecting and using in A) an aqueous solution of sodium hydroxide with a concentration of 25% to 50% by weight that produces in D) an ibuprofen sodium salt having an average particle size within a selected range of average particle sizes. |
| priorityDate | 2006-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.