| abstract |
A sphingosine-1-phosphate 2 (S1P2) receptor antagonist of the formula: ** Formula ** wherein R1 is -CH3, R2 is -CH2CO2H or -CH2CH2OH, and R3 is 2,6-dichloropyridine substituted by 4, 4-2-, 2-chloro-6-hydroxyethylpyridine, 4-2-, 2-chloro-6-hydroxypropyl-pyridine, 4, 2- (aminoethyl) -6-chloro-pyridine substituted with 4, 2- (aminoethylmethyl) -6-chloro-pyridine 4-substituted, 2,3-dichloro-thiophene, 5-substituted and its physiologically acceptable salts and solvates. |