http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2625380-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a693232b92910547c898db10feb83fef |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 |
| filingDate | 2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04d9b1d85d8edb2764a438ae14b12a09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abbd24a1535e86f59ece2445a85778b2 |
| publicationDate | 2017-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2625380-T3 |
| titleOfInvention | Procedure for the preparation of Vortioxetine |
| abstract | A process for the preparation of vortioxetine or a pharmaceutically acceptable salt thereof, a process comprising reacting a compound of formula I ** Formula ** wherein each Hal independently represents fluorine or chlorine; R 'represents H or R' represents one or two moieties independently selected from CHO, COOH, COOR '' 'or COONR2' '', or R 'represents one to five moieties independently selected from C1-6 alkyl; R '' 'independently represents H or C1-6 alkyl; and X- represents a non-coordinating and non-nucleophilic anion, with a piperazine of formula II ** Formula ** where R represents H, and with a compound of formula III ** Formula ** where R "represents H or a cation and a base as needed in a solvent to obtain a compound of formula IV ** Formula ** followed by a decompletion step in which the optionally substituted cyclopentadienyl iron is decomplexed to obtain 1- [2- (2,4- dimethyl-phenylsulfanyl) -phenyl] -piperazine (vortioxetine). |
| priorityDate | 2013-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.