| abstract |
A compound represented by the following general formula (I), or a salt thereof: ** Formula ** in which the symbols have the following meanings: ** Formula ** L: a C1-5 alkylene; ring D together with the groups represented by R6 to R9 to be joined to it form a group selected from the following formulas (a) - (d): ** Formula ** in which the symbols have the following meanings: R6a and R6b: the same or different, a hydrogen atom, a C1-5 alkyl or a halogen-substituted C1-5 alkyl, R7a, R8a, R7b and R8b: the same or different, a hydrogen atom, a halogen atom, a C1-5 alkyl or C1-5 alkyl substituted with halogen, ** Formula ** in which the symbols have the following meanings: R6c and R6d: the same or different, a hydrogen atom, a C1-5 alkyl or an alkyl C1-5 substituted with halogen, and R7c, R8c, R7d and R8d: the same or different, a hydrogen atom, a halogen atom, a C1-5 alkyl or a C1-5 alkyl substituted with halogen; ring E: is benzene; R11a and R12a: the same or different, a hydrogen atom, a C1-5 alkyl, a halogen-substituted C1-5 alkyl, -O-C1-5 alkyl, -SO2-C1-5 alkyl, -C (> = O ) H, -C (> = O) -C1-5alkyl, -CN, -NH2, -NH-C1-5alkyl, -N (C1-5alkyl) 2, -C (> = O) -NH2, -C (> = O) -NH-C1-5-alkyl, -C (> = O) -N (C1-5-alkyl) 2, -C (> = O) -aryl, -C (> = O) - NH-aryl, -NH-C (> = O) -C1-5alkyl, -NH-C (> = O) -aryl, -NH-SO2-C1-5alkyl, -N (C1-5alkyl) - SO2-C1-5alkyl, -C1-5alkylene- NH-SO2-C1-5alkyl, -C1-5alkylene-NH-SO2-aryl, -C (> = O) -O-C1-5alkyl, - C1-5 alkylene-OH, -C1-5alkylene-C (> = O) -NH-C1-5alkyl, -C1-5alkylene-C (> = O) -N (C1-5alkyl) 2, - C1-5 alkylene 5-C (> = O) -NH2, -C1-5 alkylene-C (> = O) - OH, -C1-5 alkylene-O-C1-5 alkyl, -C1-5-alkylene -C1-5alkyl, -C1-5alkylene-OC (> = O) -C1-5alkyl, -C1-5alkylene-NH-C1-5alkyl, -C1-5alkylene-N (C1-5alkyl) 2, -C1-5alkylene-aryl, a cycloalkyl, an aryl, - (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms of one or more kinds of heteroatoms selected from the group consisting of N, S, and O), -O- (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms of one or more classes of heteroatoms selected from the group consisting of N, S and O), -C1-5alkylene- (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms from one or more classes of heteroatoms selected from the group consisting of N, S, and O), -C (> = O) - (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms from one or more classes of heteroatoms selected from the group consisting of N, S, and O), -C1-5alkylene-N (C1-5alkyl) - (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms from one or more classes of heteroatoms selected from the group consisting of N, S, and O) or -C (> = O ) -NH- (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms from one or more classes of heteroatoms selected from the group that c consists of N, S, and O), and the monocyclic or bicyclic heterocycle above may be substituted with a halogen atom, a C1-5 alkyl, -O-C1-5 alkyl, or -OH; G is a ring selected from morpholine, piperidine or pyrrolidine and the nitrogen atom of the ring group ring is attached to L; R1 to R9: the same or different, a hydrogen atom, a halogen atom, a C1-5 alkyl, a C1-5 alkyl substituted with halogen, -OH, -SH, -O-C1-5 alkyl, -O- C1-5alkyl-NH-C1-5alkyl, -O-C1-5alkyl-N (C1-5alkyl) 2,> = O, -NH2, -NH-C1-5alkyl, -N (C1-alkyl 5) 2, -S-C1-5-alkyl, -SO-C1-5-alkyl, -SO2-C1-5-alkyl, -CN, - COOH, -C (> = O) -O-C1-5-alkyl, - C (> = O) -NH2, -C (> = O) -NH-C1-5-alkyl, -C (> = O) -N (C1-5-alkyl) 2, -NH-C (> = O) -C1-5alkyl, -NH-SO2-C1-5alkyl, -SO2-NH2, -SO2-NH-C1-5alkyl, -C (> = O) -C1-5alkyl, -NO2 or a saturated heterocycle containing nitrogen; R10: a hydrogen atom or a C1-5 alkyl; R13 to R15: the same or different, a hydrogen atom, a halogen atom, a C1-5 alkyl, a C1-5 alkyl substituted with halogen, -OH, -O-C1-5 alkyl, -S-C1- alkyl 5, -SO-C1-5 alkyl, -SO2-C1-5 alkyl,> = O, - C (> = O) H, -C (> = O) -C1-5 alkyl, -COOH, -CN, -NH2, -NH-C1-5-alkyl, -N (C1-5-alkyl) 2, -C (> = O) -NH2, -C (> = O) -NH-C1-5-alkyl, -C (> = O ) -N (C1-5 alkyl) 2, -C (> = O) -aryl, -C (> = O) -NH-aryl, -NH-C (> = O) -C1-5alkyl, -NH -C (> = O) -aryl, - NH-SO2-C1-5alkyl, -N (C1-5alkyl) -SO2-C1-5alkyl, -C1-5alkylene-NH-SO2-C1-5alkyl , -C1-5alkylene-NHSO2-aryl, -C (> = O) -O-C1-5alkyl, -C1-5alkylene-OH, -C1-5alkylene-C (> = O) -NH-alkyl C1-5, -C1-5 alkylene-C (> = O) -N (C1-5-alkyl) 2, -C1-5-C-alkylene (> = O) -NH2, -C1-5-C-alkylene (> = O) -OH, -C1-5alkylene-O-C1-5alkyl, - C1-5alkylene-S-C1-5alkyl, -C1-5alkylene-OC (> = O) -C1-5alkyl, -C1-5alkylene-NH-C1-5alkyl, -C1-5alkylene-N (C1-5alkyl) 2, -C1-5alkylene-aryl, a cycloalkyl, an aryl, - (monocyclic or bicyclic heterocycle or 4- to 12-membered containing 1 to 4 atoms from one or more classes of heteroatoms selected from the group consisting of N, S, and O), -O- (monocyclic or bicyclic 4- to 12-membered heterocycle containing 1 to 4 atoms from one or more classes of heteroatoms selected from the group consisting of N, S, and O), -C1-5alkylene- (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms of one or more classes of heteroatoms selected from the group consisting of N, S, and O), -C (> = O) - (monocyclic or bicyclic 4- to 12-membered heterocycle containing 1 to 4 atoms of one or more classes of heteroatoms selected from group consisting of N, S, and O), -C1-5alkylene-N (C1-5alkyl) - (4- to 12-membered monocyclic or bicyclic heterocycle containing 1 to 4 atoms from one or more selected classes of heteroatoms from the group consisting of N, S and O) or -C (> = O) -NH- (monocyclic or bicyclic 4- to 12-membered heterocycle containing 1 to 4 ato We are from one or more classes of heteroatoms selected from the group consisting of N, S, and O), and the monocyclic or bicyclic heterocycle above may be substituted with halogen atom (s), C1-5 alkyl, -O- C1-5 alkyl or -OH, or a salt thereof. |