http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2625305-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_648c9679dd9ec36125406a2dafa6bf7e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N47-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01C1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate | 2010-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a15306fb58601a471768a80444580ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_036d5ad5cb4abf58f1523a885cfe6908 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_361370bcb91f0fa6e237548a4f5a2e8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f079c4dae4d0ac863d0d7b1d01b5a285 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b7dcfadd69053fb361edd84b03235aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf6cf0155385e7f47fb85f3f7ac10fe6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3e0dfa0d38442e9c6254b88628a17fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9e251b7ac2a1e8a054e482ecae0f6e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9a825b97e620b61ec783572adad4f3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8792c8bf03e5471debfbcb531aa7b843 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8135a13d625516dd91acdb6e7aab112e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1814585aaa8ec3f6f45868b7d529b9cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fafe9ece4a7d3fb675805c00134a83a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_092efcda1b26bcae7f290e7563d0a568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11090bc9617adba7664a4a2dd70ad76d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3de7e1a79a36af75e1b8cbcf247ccba8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b262b072f1c272a0a2720d0fab158b5e |
| publicationDate | 2017-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2625305-T3 |
| titleOfInvention | Method for preparation of thiazole derivatives |
| abstract | A method comprising reacting a selected molecule of the VIIa-k molecules with the XXd molecule to form the Iv molecule. ** Formula ** wherein: (a) X is N or CR8; (b) R1 is H, F, Cl, Br, I, CN, NO2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, C2-C6 alkenyloxy substituted or unsubstituted, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C3-C10 cycloalkenyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C1-C20 heterocyclyl, OR9, C (> = X1) R9 , C (> = X1) OR9, C (> = X1) N (R9) 2, N (R9) 2, N (R9) C (> = X1) R9, SR9, S (O) nOR9 or R9S (O ) nR9, wherein each said R1, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C2- haloalkenyl C6, C1-C6 haloalkyloxy, C2-C6 haloalkenyloxy, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C3-C10 halocycloalkyl, C3-C10 halocycloalkenyl, OR9, S (O) nOR9, C6-C20 aryl or C1-C20 heterocyclyl (each of which may be substituted, may optionally be substituted with R9); (c) R2 is H, F, Cl, Br, I, CN, NO2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, C2-C6 alkenyloxy substituted or unsubstituted, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C3-C10 cycloalkenyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C1-C20 heterocyclyl, OR9, C (> = X1) R9 , C (> = X1) OR9, C (> = X1) N (R9) 2, N (R9) 2, N (R9) C (> = X1) R9, SR9, S (O) nOR9, or R9S ( O) nR9, wherein each said R2, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C2 haloalkenyl -C6, C1-C6 haloalkyloxy, C2-C6 haloalkenyloxy, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C3-C10 halocycloalkyl, C3-C10 halocycloalkenyl, OR9, S (O) nOR9, C6-C20 aryl or C1-C heterocyclyl , (each of which may be substituted, may optionally be substituted with R9); (d) R3 is H, F, Cl, Br, I, CN, NO2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, C2-C6 alkenyloxy substituted or unsubstituted, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C3-C10 cycloalkenyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C1-C20 heterocyclyl, OR9, C (> = X1) R9, C (> = X1) OR9, C (> = X1) N (R9) 2, N (R9) 2, N (R9) C (> = X1) R9, SR9, S (O) nOR9 or R9S ( O) nR9, wherein each said R3, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C2 haloalkenyl -C6, C1-C6 haloalkyloxy, C2-C6 haloalkenyloxy, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C3-C10 halocycloalkyl, C3-C10 halocycloalkenyl, OR9, S (O) nOR9, C6-C20 aryl or C1-C heterocyclyl , (each of which may be substituted, may optionally be substituted with R9); (e) R4 is H, F, Cl, Br, I, CN, NO2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, C2-C6 alkenyloxy substituted or unsubstituted, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C3-C10 cycloalkenyl, substituted or unsubstituted C1-C20 heterocyclyl, OR9, C (> = X1) R9, C (> = X1) OR9, C (> = X1) N (R9) 2, N (R9) 2, N (R9) C (> = X1) R9, SR9, S (O) nOR9 or R9S (O) nR9, where each said R4, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C1-C6 haloalkyloxy, C2 haloalkenyloxy -C6, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C3-C10 halocycloalkyl, C3-C10 halocycloalkenyl, OR9, S (O) nOR9, C6-C20 aryl or C1-C20 heterocyclyl, (each of which may be substituted, may optionally be substituted with R9); (f) R5 is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C2-C6 alkenyloxy, substituted or unsubstituted C3-C10 cycloalkyl substituted, substituted or unsubstituted C3-C10 cycloalkenyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C1-C20 heterocyclyl, OR9, C (> = X1) R9, C (> = X1) OR9, C (> = X1) N (R9) 2, N (R9) 2, N (R9) C (> = X1) R9, SR9, S (O) nOR9, R9S (O) nR9, C1-C6 alkyl aryl C6-C20 ( wherein the alkyl and aryl can independently be substituted or unsubstituted), C (> = X2) R9, C (> = X1) X2R9, R9X2C (> = X1) R9, R9X2R9, C (> = O) (alkyl C1-C6) S (O) n (C1-C6 alkyl), C (> = O) (C1-C6 alkyl) C (> = O) O (C1-C6 alkyl), (C1-C6 alkyl) OC ( > = O) (C6-C20 aryl), (C1-C6 alkyl) OC (> = O) (C1-C6 alkyl), C1-C6 alkyl- (C3-C10 cyclohaloalkyl), or (C1-C6 alkenyl) C (> = O) O (C1-C6 alkyl) or R9X2C (> = X1) X2R9; wherein each said R5, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, haloalkyloxy C1-C6, C2-C6 haloalkenyloxy, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C3-C10 halocycloalkyl, C3-C10 halocycloalkenyl, OR9, S (O) nOR9, C6-C20 aryl, or C1-C20 heterocyclyl, R9 heterocyclyl (each of which may be substituted, may optionally be substituted with R9) optionally R5 and R7 may be connected in a cyclic arrangement, where optionally such arrangement may have one or more heteroatoms selected from O, S, or N, in the cyclic structure that connects R5 and R7; (g) R6 is O, S, NR9, or NOR9; (h) R7 is substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C2-C6 alkenyloxy, substituted or unsubstituted C3-C10 cycloalkyl, C3-C10 substituted or unsubstituted cycloalkenyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C1-C20 heterocyclyl, OR9, OR9S (O) nR9, C (> = X1) R9, C (> = X1) OR9 , R9C (> = X1) OR9, R9X2C (> = X1) R9X2R9, C (> = X1) N (R9) 2, N (R9) 2, N (R9) (R9S (O) nR9), N (R9 ) C (> = X1) R9, SR9, S (O) nOR9, R9S (O) nR9, C1-C6 alkyl (> = O) C1-C6 alkyl, C1-C6 alkyl-C1-C20 heterocyclyl, C1- alkyl C6-C1-C20 heterocyclyl, C1-C6S alkyl (> = N-CN) (C1-C6 alkyl), C1-C6S alkyl (O) (> = N20 CN) (C1-C6 alkyl), C1-C6S alkyl ( O) n (C1-C6-C1-C20-heterocyclyl alkyl), C1-C6S alkyl (O) (> = N-CN) (C1-C6 alkyl-C1-C20 heterocyclyl), C1-C6NH alkyl (C (> = O ) C1-C6 alkyl), C1-C6-C alkyl (> = O) C1-C6 alkyl, C1-C6 alkyl (C6-C20 aryl) NH (C (> = O) C1-C6 alkyl), C1- alkyl C6 (S-C1-C6 alkyl) NH (C (> = O) Oalkyl or C1-C6), C1-C6 alkyl (S-C1-C6 alkyl-C6-C20 aryl) NH (C (> = O) C1-C6 alkyl), C1-C6 alkyl (NHC (> = O) C1 alkyl -C6-C6-C20 aryl) NH (C (> = O) C1-C6 alkyl), C1-C6 alkyl (C1-C6 alkyl-C6-C20 aryl) NH (C> = O) C1-C6 alkyl), C1-C6N alkyl (C1-C6 alkyl) (C (> = O) C1-C6 alkyl), C1-C6NH alkyl (C1-C6 alkyl), C6-C20-S-halo C1-C6 alkyl, C1-C6 alkyl -N (C1-C6 alkyl) (C (> = O) C1-C6 alkyl-C6-C20 aryl), C1-C6-N alkyl (C1-C6 alkyl) (C1-C6 alkyl), C1-C6N alkyl ( C1-C6 alkyl) (S (O) C1-C6 alkyl), C1-C6lN alkyl (C1-C6 alkyl) (S (O) C1-C6 nalkenyl-C6-C20 aryl), C1-C6N alkyl (C1- alkyl C6) (C (> = O) C1-C20 heterocyclyl), C1-C6N alkyl (C1-C6 alkyl) (C (> = O) C1-C6 alkyl-C6-C20 aryl), NH (C1-C6S alkyl ( O) C1-C6 alkyl), NH (C1-C6S alkyl (O) C6-C20 naryl), C1-C6 alkyl (S (O) C1-C6 alkyl) (C (> = O) C1-C6S alkyl (O ) n (C1-C6 alkyl) or R9S (O) n (NZ) R9, wherein each said R7, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1 alkyl -C6, C2-C6 alkenyl, C1 haloalkyl -C6, C2-C6 haloalkenyl, C1-C6 haloalkyloxy, C2-C6 haloalkenyloxy, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C3-C10 halocycloalkyl, C3-C10 halocycloalkenyl, OR9, S (O) C6- C20 aryl , or C1-C20 heterocyclyl, (each of which may be substituted, may optionally be substituted with R9), C (> = X1) R9, C (> = X1) OR9, C (> = X1) N (R9 ) 2,> = X2, N (R9) 2, S (> = X2) nR9, R9S (O) nR9, S (O) nN (R9) 2; (i) R8 is H, F, Cl, Br, I, CN, NO2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, C2-C6 alkenyloxy substituted or unsubstituted, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C3-C10 cycloalkenyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C1-C20 heterocyclyl, OR9, C (> = X1) R9 , C (> = X1) OR9, C (> = X1) N (R9) 2, N (R9) 2, N (R9) C (> = X1) R9, SR9, S (O) nR9, S (O ) nOR9 or R9S (O) nR9, wherein each said R8, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, C2-C6 alkenyl, C1 haloalkyl -C6, C2-C6 haloalkenyl, C1-C6 haloalkyloxy, C2-C6 haloalkyloxy, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C3-C10 halocycloalkyl, C3-C10 halocycloalkenyl, OR9, S (O) C-C20 aryl, C20 or C1-C20 heterocyclyl, (each of which may be substituted, may optionally be substituted with R9); (j) R9 (each independently) is H, CN, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C2-C6 alkenyloxy, C3-C10 substituted or unsubstituted cycloalkyl, substituted or unsubstituted C3-C10 cycloalkenyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C1-C20 heterocyclyl, S (O) C1-C6 alkyl,, N (C1 alkyl -C6) 2, wherein each said R9, which is substituted, has one or more substituents selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, haloalkenyl C2-C6, haloalkyloxy C1-C6, haloalkenyloxy C2-C6, cycloalkyl C3-C10, cycloalkenyl C3-C10, halocycloalkyl C3-C10, halocycloalkenyl C3-C10, Oalkyl C1-C6, Ohaloalkyl C1-C6, S (O) C1-C6 alkyl, S (O) n C1-C6 alkyl, C6-C20 aryl or C1-C20 heterocyclyl; (k) n is 0, 1 or 2; (l) X1 is (each independently) O or S; (m) X2 is (each independently) O, S,> = NR9 or> = NOR9; and (n) Z is CN, NO2, C1-C6 alkyl (R9), C (> = X1) N (R9) 2. |
| priorityDate | 2009-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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