http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2624622-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bb2c65fed767c6cdb08ca3b49dbb9f0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5383 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2009-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b848418853f3eaf218be7c97d48794ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_457b7178efb5bb74cbdaa64d2772015c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9051b9c81c7d8ec9bd7cd4978a99d3b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10e041d8dbdace05dc8bbc327f98ac99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd9a6d04929edd22cd40f04497915d3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b493a8b1cbf357885a80eef35bae032 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a296563f4d7c9888db6bd569b638fc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87f70a917d0068e4dd798675cb7c7d18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1667d14b86cb687a6ac6ff89f2f07c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff87955ae2d8799a7cb641482e5767ff |
| publicationDate | 2017-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2624622-T3 |
| titleOfInvention | Pyrimidinediamine kinase inhibitors |
| abstract | A compound that is according to Formula I: ** Formula ** or is a pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein: Y1 is O or S; Z1 is CH or N; A is phenyl or a 6-membered heteroaryl; R1 is H; each of R2 and R3 is, independently of each other, H, (C1-C6) alkyl optionally substituted with one or more of the same or different R11 groups, (C3-C8) cycloalkyl optionally substituted with one or more of the R11 groups same or different, cycloalkylalkyl (C4-C11) optionally substituted with one or more of the same or different R11 groups, aryl (C5-C10) optionally substituted with one or more of the same or different R11 groups, arylalkyl (C6-C16) optionally substituted with one or more of the same or different R11 groups, 2-6 membered heteroalkyl optionally substituted with one or more of the same or different R11 groups, 3-8 cycloheteroalkyl, optionally substituted with one or more of the groups Same or different R11, 4-11 membered cycloheteroalkylalkyl, optionally substituted with one or more of the same or different R11 groups, 5-10 membered heteroaryl optionally substituted with one or more of the same R11 groups s or different, or 6-16 membered heteroarylalkyl optionally substituted with one or more of the same or different R11 groups; each of R4 and R5 is, independently of each other, H, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, halogen, halo (C1-C6) haloalkoxy (C1-C6) alkyl or hydroxyalkyl (C1-C6); or, alternatively, R4 and R5, taken together with the carbon atom to which they are attached, form a spirocycloalkyl or a spirocycloheteroalkyl, or, alternatively, R4 and R5, taken together with the carbon atom to which they are attached, form a group C> = O; each of R6 and R7 is, independently of each other, H, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, halogen, halo (C1-C6) haloalkoxy (C1-C6) alkyl or hydroxyalkyl (C1-C6); or, alternatively, R6 and R7, taken together with the carbon atom to which they are attached, form a spirocycloalkyl or a spirocycloheteroalkyl or, alternatively, R6 and R7, taken together with the carbon atom to which they are attached, form a group C> = O; R8 is H, halo, (C1-C6) alkyl optionally substituted with one or more of the same or different R11 groups, haloalkyloxy (C1-C3), -ORd, -SRd, -NRcRc, haloalkyl (C1-C3), - C (O) ORd, - CN, -NC, -OCN, -SCN, -NO or -NO2; two R9, taken together with the nitrogen atom to which they are attached, form a 6 to 10 membered bridged bicyclic cycloheteroalkyl, or a 6 to 12 membered bridged tricyclic cycloheteroalkyl, in which each may be optionally substituted with one or more of the same or different R11 groups, and wherein the substituted or unsubstituted bi or tricyclic cycloheteroalkyl includes at least two nitrogen atoms; each R10 is independently R11 or, alternatively, two R10 in the adjacent carbons, taken together with the carbons to which they are attached, form a condensed ring to A, where the condensed ring to A is a 5 to 8 membered cycloalkyl, a 5 to 8 membered cycloheteroalkyl, 5 to 6 membered aryl or a 5 to 6 membered heteroaryl, each optionally substituted with one or more of the same or different R11 groups; each R11 is independently H, Re, Rb, Re substituted with one or more of the same or different Ra and / or Rb, - ORe substituted with one or more of the same or different Ra and / or Rb, -SRe substituted with one or more of the same or different Ra and / or Rb, -C (O) Re substituted with one or more of the same or different Ra and / or Rb, -N (Ra) Re where Re is substituted with one or more of the same or different Ra and / or Rb, -S (O) 2Re substituted with one or more of the same or different Ra and / or Rb, -N (Ra) -S (O) 2Re, where Re is substituted with one or more of the same or different Ra and / or Rb, -B (ORa) 2, -B (N (Rc) 2) 2, - (C (Ra) 2) m-Rb, -O- (C (Ra ) 2) m-Rb, -S- (C (Ra) 2) m-Rb, -O- (C (Rb) 2) m-Ra, -N (Ra) - (C (Ra) 2) m- Rb, -O- (CH2) m-CH ((CH2) mRb) Rb, -C (O) N (Ra) - (C (Ra) 2) m-Rb, -O- (C (Ra) 2) mC (O) N (Ra) - (C (Ra) 2) m-Rb, - N ((C (Ra) 2) mRb) 2, -S- (C (Ra) 2) mC (O) N ( Ra) - (C (Ra) 2) m-Rb, -N (Ra) -C (O) -N (Ra) - (C (Ra) 2) m-Rb, -N (Ra) -C (O ) - (C (Ra) 2) m- C (Ra) (Rb) 2 or -N (Ra) - (C (Ra) 2) mC (O) -N (Ra) - (C (Ra) 2) m-Rb; each Ra is independently H, deuterium, (C1-6) alkyl, cycloalkyl (C3-8), cycloalkylalkyl (C4-11), aryl (C6-10), arylalkyl (C7-16), 2-6 membered heteroalkyl, 3-10 membered heteroalicyclyl, 4-11 membered heteroalicyclyl alkyl, 5-15 membered heteroaryl or 6-16 membered heteroarylalkyl; each Rb is independently> = O, -ORa, -O- (C (Ra) 2) m-ORa, haloalkyloxy (C1-3), -OCF3,> = S, -SRa,> = NRa,> = NOR3, -N (Rc) 2, halo, -CF3, -CN, -NC, -OCN, -SCN, -NO, -NO2,> = N2, -N3, -S (O) Ra, -S (O) 2Ra , -SO3Ra, - S (O) N (Rc) 2, -S (O) 2N (Rc) 2, -OS (O) Ra, -OS (O) 2Ra, -OSO3Ra, -OS (O) 2N ( Rc) 2, -C (O) Ra, -CO2Ra, -C (O) N (Rc) 2, - |
| priorityDate | 2008-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 296.