http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2624379-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4bdd40041a585b2fbeb8bad59beb1449 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-06 |
| filingDate | 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5205cba1689e3eb59461bc8513ac3ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c38c48d220556f636b8b38ed366a4e44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_195bc4e4790bc54d2aa68bac6137642d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_675aeb1741f1849ad0a550f37d65aaec |
| publicationDate | 2017-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2624379-T3 |
| titleOfInvention | Heterocyclyl derivatives and their use as modulators of the prostaglandin D2 receptor |
| abstract | A compound of formula (I): ** Formula ** in which R1 represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, fluoro (C1-C4) alkyl, (C1-C4) alkylsulfonyl, halogen or cyano; R2 represents hydrogen or halogen; one of R3, R4 and R5 represents carboxy-C1-C3 alkyl, carboxy-cyclopropyl or carboxy-C1-C3 alkoxy and the other two independently represent each other hydrogen, C1-C4 alkoxy or halogen; R6 represents hydrogen, (C1-C4) alkoxy or halogen; R7 represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C3-C6) cycloalkyl-methoxy, (C3-C6) cycloalkyloxy, methoxyethoxy, di- (C1-C2) alkyl - amino, fluoroalkyl (C1-C4), fluoroalkoxy (C1-C4), halogen or (C1-C4) alkylsulfonyl; or R6 and R7 together represent methylenedioxy or ethylenedioxy; R8 represents: - (C2-C5) alkyl; - (C1-C5) alkyl which is mono- or di-substituted where the substituents are independently selected from the group consisting of hydroxy, (C1-C4) alkoxy, oxo, -NR9R10, (C3-C6) cycloalkyl in which the (C3-C6) cycloalkyl groups are unsubstituted or mono-substituted with (C1-C4) alkyl, (C1-C4) alkoxy, hydroxyl or phenyl which is unsubstituted or mono-substituted with halogen, and in which a cycloalkyl group Containing four, five, or six carbon atoms, it can be optionally ringed to a benzene ring or a pyridine ring, wherein the benzene ring is optionally mono-substituted with methoxy; aryl in which the term "aryl" means a phenyl group or a naphthyl group groups that are independently unsubstituted, mono-, di-, or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, alkyl (C1-C4), (C1-C4) alkoxy, fluoro (C1-C4) alkyl, and fluoroalkoxy (C1-C4); heteroaryl in which the term "heteroaryl" means a 5- to 10-membered monocyclic or bicyclic aromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from oxygen, nitrogen and sulfur and in which heteroaryl groups are independently unsubstituted , mono-, di- or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, (C1-C4) alkoxy, and (C1-C4) fluoroalkyl; heterocyclyl in which the term "heterocyclyl" means a 5- to 7-membered saturated monocyclic moiety containing 1 or 2 heteroatoms selected from nitrogen, oxygen and sulfur, it being understood that a heterocyclyl group does not contain 2 sulfur atoms, wherein the sulfur atom of a heterocyclyl group may be in an oxidized form, in which a heterocyclyl group may optionally be annealed to a benzene ring or to a pyridine ring in which the benzene ring is optionally mono-substituted with fluoro, and wherein the heterocyclyl groups are independently unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of halogen, oxo, and (C1-C4) alkyl; aryloxy in which the term "aryloxy" means a phenyloxy or naphthyloxy group, groups that are independently unsubstituted, mono-, tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1- alkyl) C4), (C1-C4) alkoxy and fluoro (C1-C4) alkyl; heteroaryloxy where the term "heteroaryl" means a 5 to 10 membered monocyclic or bicyclic aromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from oxygen, nitrogen and sulfur and where heteroaryloxy groups are independently unsubstituted , mono-, di- or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, (C1-C4) alkoxy and (C1-C4) fluoroalkyl; or arylalkyl (C1-C2) in which the term "aryl" means a phenyl or a naphthyl group and in which the aryl groups are independently unsubstituted, mono-, di- or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, (C1-C4) alkoxy and fluoro (C1-C4) alkyl; - (C3-C5) alkenyl; - (C2-C3) alkenyl which is mono-substituted with aryl in which the term "aryl" means a phenyl group or a naphthyl group which are independently unsubstituted, mono-, di- or tri-substituted groups, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, (C1-C4) alkoxy, and fluoro (C1-C4) alkyl; or heteroaryl in which the term "heteroaryl" means a 5 to 10 membered monocyclic or bicyclic aromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from oxygen, nitrogen and sulfur and in which heteroaryl groups are independently not substituted, mono-, di- or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, (C1-C4) alkoxy and (C1-C4) fluoroalkyl; - (C3-C5) alkynyl; - (C3-C6) cycloalkyl which is unsubstituted, mono-, di-, tri- or tetra-substituted with methyl; mono-substituted with oxo; mono-substituted with aryl in which the term "aryl" means a phenyl group or a naphthyl group that are independently unsubstituted, mono-, di- or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, (C1-C4) alkoxy and fluoro (C1-C4) alkyl; or mono-substituted with heteroaryl in which the term "heteroaryl" means a 5- to 10-membered monocyclic or bicyclic aromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from oxygen, nitrogen and sulfur and in which groups Heteroaryl are independently unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, (C1-C4) alkoxy, and (C1-C4) fluoroalkyl ); or - heterocyclyl which is optionally mono-substituted with oxo; R9 represents (C1-C4) alkyl; R10 represents diphenylmethyl in which phenyl groups are independently unsubstituted or mono-substituted with halogen; n represents 1 or 2; m represents 1 or 2; and Z represents -NH-, -O- or a bond; or a salt of said compound. |
| priorityDate | 2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 68.