http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2624241-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10d432da23a2d042b6822de00c28f98d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-59 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2869 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2003-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3525c4972ad18e0436f1f6d5f42b22d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b3355ee0e879ff9bbd0dcec79f4c0dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bce0f0cd822e127393b6291944ebda68 |
| publicationDate | 2017-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2624241-T3 |
| titleOfInvention | Thyrotropin receptor antibody and its uses |
| abstract | A screening procedure for autoantibodies for the TSH receptor in a sample of body fluid obtained from a subject suspected of suffering from, who is susceptible to, having or recovering from, an autoimmune disease associated with an immune reaction to the recipient of TSH, said method comprising: (a) Providing one or more pairs of binding molecules, wherein a first molecule of said binding pair comprises a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the receptor of TSH, or an additional antibody or fragment thereof for the TSH receptor that competes for binding to the TSH receptor with said human monoclonal or recombinant antibody or fragment thereof, wherein said first molecule is characterized by an inhibitory activity with respect to the binding of 125I-labeled TSH to the TSH receptor determined using tubes coated with TSH receptor of at least 15 units of this International NIBSC 90/672 per mg; and a second molecule of said binding pair is a full-length TSH receptor, one or more epitopes of a TSH receptor or a polypeptide comprising one or more epitopes of a TSH receptor; (b) contacting said sample with said one or more pairs of binding molecules to allow said second molecule of said binding pair to interact well with (i) autoantibodies for the TSH receptor present in said sample, or (ii ) with said human monoclonal or recombinant antibody or one or more fragments thereof, or said additional antibody or fragment thereof for the TSH receptor, and (c) controlling the interaction of said second molecule of said binding pair with said antibodies present in said sample, thus providing an indication of the presence of said autoantibodies for the TSH receptor in said sample. |
| priorityDate | 2002-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.