| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8ae50a1ac4cd76423a4efc15db872d1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-31 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-286
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3244
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3274 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J20-286
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-31 |
| filingDate |
2009-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec01bbad20f20963a944af24ddeb1e9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7efbb4a985aa5aa01b91e91e1f08f418
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9acf44c7a9e33dbbc427a7b2773d4bec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_184c71cd8ce53dba72b40dd98a5ce230 |
| publicationDate |
2017-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2623889-T3 |
| titleOfInvention |
Stable chromatography ligands in caustic medium |
| abstract |
A stable affinity chromatography ligand in alkaline medium, comprising two or more C domains of Staphylococcus Protein A (SpA) bound to a solid support by a multipoint binding, in which at least one domain comprises: a) a sequence of amino acids set forth in SEQ ID NO: 11 or an amino acid sequence encoded by the amino acid sequence set forth in SEQ ID NO: 5; or b) an amino acid sequence that has a sequence identity of at least 95% with the amino acid sequence set forth in SEQ ID NO: 11 or an amino acid sequence that has a sequence identity of at least 95% with the sequence of amino acids encoded by the amino acid sequence set forth in SEQ ID NO: 5; and wherein each C domain comprises a substitution of glycine at position 29 with an amino acid other than alanine or tryptophan and in which additionally the ligand retains at least 95% of its binding capacity after 5 hours of incubation in NaOH 0.5 M. |
| priorityDate |
2008-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |