http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2623491-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da0ce34460c654b33b5d997a7a57ceb1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 |
| filingDate | 2011-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_727f601c841a916443857e4f3a14f6d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93fa0dba4d68ca7ffbb6390ac4f7ff29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e12199f5ce436874ad09dc58886c4db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3701b6a9d36de5b19de86a3f58e4b10d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61b4fe147feaa09d3327d2948820f507 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0c8a330bbbff5fe8e8b115ff989e9fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0623d6ff06663ef9f426d0d1be9c2313 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc525931a9c27ab8eb7de18573d338ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76323755c5cd531951976efd1800b99d |
| publicationDate | 2017-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2623491-T3 |
| titleOfInvention | GCs stimulators |
| abstract | A compound according to Formula I, or a pharmaceutically acceptable salt thereof, ** Formula ** wherein: ring B is phenyl or a 6-membered heteroaryl ring, containing 1 or 2 ring nitrogen atoms; n is an integer selected from 1 to 3; each JB is independently selected from halogen, a C1-6 aliphatic group, or -ORB; wherein each said C1-6 aliphatic group is optionally and independently substituted with up to 3 examples of R3; each RB is independently selected from hydrogen, a C1-6 aliphatic group or a C3-8 cycloaliphatic group; wherein each said C1-6 aliphatic group and each said C3-8 cycloaliphatic ring are optionally and independently substituted with up to 3 examples of R3; each R3 is independently selected from halogen, -CN, C1-4 alkyl, C1-4 haloalkyl, -O (C1-4 alkyl) or -O (C1-4 haloalkyl); X is selected from N, C-JD or C-H; or is an integer selected from 0 to 3: each JD is independently selected from halogen, -NO2, -ORD, -SRD, -C (O) RD, -C (O) ORD, -C (O) N (RD ) 2, -CN, -N (RD) 2, -N (Rd) C (O) RD, -N (Rd) C (O) ORD, -SO2RD, -SO2N (RD) 2, -N (Rd) SO2RD, a C1-6 aliphatic group, - (C1-6 aliphatic) -RD, a C3-8 cycloaliphatic ring, a phenyl ring, a 4- to 8-membered heterocyclic ring or a 5- to 10-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5 to 10-membered heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said phenyl ring, each said 4 to 8 membered heterocyclic ring and each said 5 to 10 membered heteroaryl ring is optionally and independently substituted with up to 3 examples of R5; each RD is independently selected from hydrogen, a C1-6 aliphatic group, - (C1-6 aliphatic) -Rf, a C3-8 cycloaliphatic ring, a 4- to 8-membered heterocyclic ring, phenyl or a 5- to 6-heteroaryl ring members; wherein each said 4- to 8-membered heterocyclic ring and each said 5- to 6-membered heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 4 to 8 membered heterocyclic ring, each said phenyl and each said 5 to 6 membered heteroaryl ring is optionally and independently substituted with up to 3 examples of R5; each Rd is independently selected from hydrogen, a C1-6 aliphatic group, - (C1-6 aliphatic) -Rf, a C3-8 cycloaliphatic ring, a 4- to 8-membered heterocyclic ring, phenyl or a 5- to 6-heteroaryl ring members; wherein each said heterocyclic ring and each said heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 4 to 8 membered heterocyclic ring, each said phenyl and each said 5 to 6 membered heteroaryl ring is optionally and independently substituted by up to 3 examples of R5; each Rf is independently selected from a C3-8 cycloaliphatic ring, a 4- to 8-membered heterocyclic ring, phenyl or a 5- to 6-membered heteroaryl ring; wherein each said heterocyclic ring and each said heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 4 to 8 membered heterocyclic ring, each said phenyl and each said 5 to 6 membered heteroaryl ring is optionally and independently substituted by up to 3 examples of R5; alternatively, two examples of RD attached to the same JD nitrogen atom, together with said JD nitrogen atom, form a 4- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each heteroaryl ring 5-member said is optionally and independently substituted by up to 3 examples of R5; or alternatively, an example of RD attached to a carbon, oxygen or sulfur atom of JD and an example of Rd attached to a nitrogen atom of the same JD, together with said carbon, oxygen or sulfur and said nitrogen atom of JD itself, form a 4- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each heteroaryl ring 5-member said is optionally and independently substituted by up to 3 examples of R5; each R5 is independently selected from halogen, -CN, -NO2, C1-4 alkyl, a C7-12 aralkyl, C3-8 cycloalkyl ring, C1-4 haloalkyl, C1-4 cyanoalkyl, -OR6, -SR6, -COR6, -OCOR6, -C (O) OR6, -C (O) N (R6) 2, -N (R6) C (O) R6, -N (R6) 2, -SO2R6, -SO2N (R6) 2, - N (R6) SO2R6, phenyl or an oxo group; wherein each said phenyl group is optionally and independently substituted with up to 3 examples of halogen, -OH, -NH2, -NH (C1-4 alkyl), -N (C1-4 alkyl) 2, -NO2, -CN, alkyl C1-4, C1-4 haloalkyl, -O (C1-4 alkyl) or -O (C1-4 haloalkyl); and wherein each said C7-12 aralkyl and each said cycloalkyl group is optionally and independently substituted with up to 3 examples of halogen; each R6 is independently selected from hydrogen, a C1-4 alkyl, a C2-4 alkenyl, phenyl, a C7-12 aralkyl or a C3-8 cycloalkyl ring; wherein each of said C1-4 alkyl, each of said C2-4 alkenyl, each said phenyl, each said C7-12 aralkyl and each said cycloalkyl group is optionally and independently substituted with up to 3 examples of halogen; alternatively two examples of R6 attached to the same nitrogen atom of R5, together with said nitrogen atom of R5, form a 5- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5- to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S; or alternatively, an example of R6 attached to a nitrogen atom of R5 and an example of R6 attached to a carbon or sulfur atom of the same R5, together with said nitrogen and said carbon or sulfur atom of the same R5, form a 5- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5- to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S; or, alternatively, two JD groups attached to two neighboring D-ring atoms, taken together with said two neighboring D-ring atoms, form a 5- to 7-membered heterocycle resulting in a condensed D-ring wherein said heterocycle of 5 to 7 members contain 1 to 3 heteroatoms independently selected from N, O or S; and wherein said 5- to 7-membered heterocycle is optionally and independently substituted with up to 3 examples of halogen, -OH, -NH2, -NH (C1-4 alkyl), -N (C1-4 alkyl) 2, -CN, C1-4 alkyl, C1-4 haloalkyl, -O (C1-4 alkyl), -O (C1-4 haloalkyl), oxo or phenyl; wherein said phenyl is optionally and independently substituted with up to three examples of halogen, -OH, -NH2, -NH (C1-4 alkyl), -N (C1-4 alkyl) 2, -NO2, -CN, C1- alkyl 4, C1-4 haloalkyl, -O (C1-4 alkyl) or -O (C1-4 haloalkyl); RC is selected from -CN, C1-6 alkyl or a C ring; the C ring is a phenyl ring, a 5- or 6-membered monocyclic heteroaryl ring, an 8 to 10 membered bicyclic heteroaryl ring, a 3 to 10 membered monocyclic cycloaliphatic ring, or a 4 to 10 membered monocyclic heterocycle; wherein said 5 or 6 membered monocyclic heteroaryl ring, said 8 to 10 membered bicyclic heteroaryl ring or said 4 to 10 membered monocyclic heterocycle contains between 1 and 4 heteroatoms selected from N, O or S; wherein said 5 or 6 membered monocyclic heteroaryl ring is not a 1,3,5-triazinyl ring; and wherein said phenyl, 5 to 6 membered monocyclic heteroaryl ring, 8 to 10 membered bicyclic heteroaryl ring, or 4 to 10 membered monocyclic heterocycle is optionally and independently substituted with up to 3 JC examples; each JC is independently selected from halogen, -CN, -NO2, a C1-6 aliphatic group, -ORH, -SRH, -N (RH) 2, a C3-8 cycloaliphatic ring or a 4- to 8-membered heterocyclic ring; wherein said 4- to 8-membered heterocyclic ring contains 1 or 2 heteroatoms independently selected from N, O or S; wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring and each said 4- to 8-membered heterocyclic ring, is optionally and independently substituted with up to 3 examples of R7; or alternatively, two JC groups attached to two neighboring C ring atoms, taken together with two said neighboring C ring atoms, form a 5- to 7-membered heterocycle that results in a condensed C ring; wherein said 5 to 7 member heterocycle contains 1 to 2 heteroatoms independently selected from N, O or S; each RH is independently selected from hydrogen, a C1-6 aliphatic group, a C3-8 cycloaliphatic ring or a 4- to 8-membered heterocyclic ring; wherein each said 4 to 8-membered heterocyclic ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 4 to 8-membered heterocyclic ring, is optionally and independently substituted with up to 3 examples of R7; alternatively, two examples of RH attached to the same JC nitrogen atom, together with said JC nitrogen atom, form a 4- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each heteroaryl ring 5-member said is optionally and independently substituted by up to 3 examples of R7; or each R7 is independently selected from halogen, -CN, -NO2, C1-4 alkyl, C1-4 haloalkyl, C3-8 cycloalkyl ring, -OR8, -SR8, -N (R8) 2, or an oxo group; wherein each said cycloalkyl group is optionally and independently substituted with up to 3 examples of halogen; each R8 is independently selected from hydrogen, a C1-4 alkyl, C1-4 haloalkyl or a C3-8 cycloalkyl ring; wherein each said cycloalkyl group is optionally and independently substituted with up to 3 examples of halogen; alternatively, two examples of R8 attached to the same nitrogen atom of R7, together with said nitrogen atom of R7, form a 5- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5- to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S; RA is selected from hydrogen, halogen, C1-4 alkyl or C1-4 haloalkyl |
| priorityDate | 2010-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1287.