http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2623262-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c13193fe65025a46525ac2b48f75f12a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 |
| filingDate | 2013-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_771d8848286d3ecae511ee56850e1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98f9cd6e70ced01595764be814d6ca14 |
| publicationDate | 2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2623262-T3 |
| titleOfInvention | Morphinan derivatives containing nitrogen and their use |
| abstract | A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is hydrogen, OH, halogen, cyano, carboxy, or aminocarbonyl; or alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, or alkynyloxy, either of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, halogen, haloalkyl, amino, alkylamino, dialkylamino, carboxy , alkoxy, alkoxycarbonyl, aryl, heteroaryl, heterocycle, cycloalkyl and cycloalkenyl, wherein said aryl, heteroaryl, heterocycle, cycloalkyl and cycloalkenyl are optionally substituted with 1, 2 or 3 independently selected R11 groups; or -O-PG, where PG is a hydroxyl protecting group; R2 is (a) hydrogen or carboxamido; or (b) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, (cycloalkyl) alkyl, (cycloalkenyl) alkyl, (heterocyclo) alkyl, arylalkyl, heteroarylakylalkyl, alkylcarbonyl, alkoxycarbonyl, (arylalkylkoxy) carbonyl ) carbonyl, any one of which is optionally substituted with 1, 2 or 3 substituents, each independently selected from the group consisting of hydroxy, alkyl, halogen, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, aryl, heteroaryl , heterocycle, cycloalkyl and cycloalkenyl, wherein said aryl, heteroaryl, heterocycle, cycloalkyl and cycloalkenyl are optionally substituted with 1, 2 or 3 independently selected R11 groups; R3 is hydrogen, OH or halogen; or alkoxy, alkylamino or dialkylamino, either of which is optionally substituted with 1, 2 or 3 substituents, each independently selected from the group consisting of hydroxyl, halogen, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, aryl , heteroaryl, heterocycle, cycloalkyl and cycloalkenyl, wherein said aryl, heteroaryl, heterocycle, cycloalkyl and cycloalkenyl are optionally substituted with 1, 2 or 3 independently selected R11 groups; R4 is hydrogen; or R3 and R4 together form a bond; Z is selected from the group consisting of a) hydrogen, b) (cycloalkyl) alkyl, c) (cycloalkenyl) alkyl, d) arylalkyl, e) heteroarylalkyl, f) (heterocycle) alkyl, g) -alkyl-C (> = O) NR5R6, h) -alkyl-C (> = O) OR7, i) -C (> = O) -alkyl-NR8R9, j) -C (> = O) -alkyl-OR10, and k) cyanoalkyl, in where the cycloalkyl, aryl, heteroaryl and heterocycle portions are optionally substituted with 1, 2 or 3 substituents, each independently selected from the group consisting of alkyl, hydroxy, halogen, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl and aminocarbonyl; and wherein R5, R6, R7, R8, R9 and R10 are each independently selected from the group consisting of hydrogen, alkyl and aryl, wherein the alkyl and aryl groups are optionally substituted with 1 or 2 substituents, each independently selected from the group consisting of alkyl, hydroxy, halogen, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl and aminocarbonyl; each R11 is independently selected from the group consisting of hydroxy, alkyl, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy and alkoxycarbonyl; and Y is C> = O or CH2. |
| priorityDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 234.