http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2623094-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42b66fd6ac8d432f925152eef843ebe7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-245 |
| filingDate | 2002-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa0c1efb04efb23a730e187721a43f73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1820390d30d6da990e920ea24f86e39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fa621fad1901b5e126eb1c69813ecc0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f6bb24f84e791b42765ae6d8b770f28 |
| publicationDate | 2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2623094-T3 |
| titleOfInvention | Methods of preparing crystals that include a malic acid salt of N- [2- (diethylamino) ethyl] -5 - [(5-fluoro-1,2-dihydro-2-oxo-3H-indole-3-ylidene) methyl] -2,4-dimethyl-1H-pyrrole-3-carboxamide |
| abstract | A process for preparing an anhydrous crystal comprising an L-malic acid salt of N- [2- (diethylamino) ethyl] -5 - [(5-fluoro-1,2-dihydro-2-oxo-3H-indole -3-ylidene) methyl] -2,4-dimethyl-1H-pyrrole-3-carboxamide in which the anhydrous crystal has characteristic diffraction peaks at 13.2 and 24.2 degrees two theta in a ray diffraction pattern X of powder, the process comprising: combining L-malic acid; N- [2- (diethylamino) ethyl] -5 - [(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl] -2,4-dimethyl-1H-pyrrole- 3-carboxamide; and a solvent; and inducing the salt to crystallize under crystallization conditions comprising one or more factors comprising: a difference between the initial and final temperatures of the maximum crystallization solution approximately 100 ° C; a maximum cooling rate of approximately 50 ° C per hour; no sowing; a maximum supersaturation ratio approximately 10; without precipitant; and / or combinations thereof. |
| priorityDate | 2001-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.