| abstract |
Protein or polypeptide for use in therapy, protein or polypeptide containing an individual variable domain of immunoglobulin (ISV) at its C-terminal end, wherein said ISV is either a VHH, optimized sequence VHH, humanized VHH or VH Camelized, or is an ISV comprising a VH sequence other than a VHH, optimized sequence VHH, humanized VHH or camelized VH or derived from a VH sequence, ISV having a C-terminal end of the VTVSS sequence ( X) n, in which: - n> = 1, 2 or 3 in which each X> = Ala or Gly; or - n> = 1, 2 or 3 in which each X> = Ala; o - n> = 1, 2 or 3 in which each X> = Gly; or - n> = 2 or 3 in which at least one X> = Ala or Gly; or - n> = 2 or 3 in which all but one X> = Ala or Gly, and protein or polypeptide that includes a seroalbumin binding peptide or seroalbumin binding domain and has a half-life expressed as t1 / 2-beta in a human subject of at least 3 days. |