http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2621220-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D273-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab4c198d475601e55fce4d235ade8554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3ea68338321fd37fee840ef77d3a1b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc19e9ddcf7bd4d5f2337da4635afd9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b58970538a33ca643afebd86c26a59f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9499c721ed6755e83739b6e85b2ac2a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37eeb50853de84c30bd9aef782b7c972 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df081d8c8beac02a5d3c509fc26fe4c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c70629a32bd49180676730134ee3c591 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8cfd7cdfcbc57e650fdd64186a9c185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25b0920f874a95fcb224c792e338d494 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_137ec7372a71e3629448a959f476a0a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e957e37f9ca9a2fc97a53135a37059a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d63049f2b60a439b6c81efe939cc55c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3833b1a65dceda3d984e8342c27749a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a9ca783784743b823a7bc5cde61b2e0 |
| publicationDate | 2017-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2621220-T3 |
| titleOfInvention | Macrocyclic derivatives for the treatment of proliferative diseases |
| abstract | A compound of formula (I) ** Formula ** in which: X is selected from the group consisting of - (CR5R6) qO (CR5R6) r-, - (CR5R6) qN (R1) (CR5R6) r-, - (CR5R6) qC (O) N (R1) (CR5R6) r- and - (CR5R6) qN (R1) C (O) (CR5R6) r-; Y and Z are each independently N or CH, with the proviso that when Y is N, Z is CH and when Z is N, Y is CH; A is a ring selected from C6-C12 aryl and 5-6 membered heteroaryl; R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic and 5-6 membered heteroaryl, wherein each hydrogen in said C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic and 5-6 membered heteroaryl optionally may be optionally substituted halogen independent, -OH, -NH2, -S (O) tR9, -S (O) 2NR9R10, -S (O) 2OR9, -NO2, -CN, -OR9, -C (O) R9, -OC ( O) R9, -NR9C (O) R10, - C (O) OR9, -C (> = NR9) NR9R10, -NR9C (O) NR9R10, -NR9S (O) 2R10 or -C (O) NR9R10; each R2 is independently selected from the group consisting of halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic, 5-6 heteroaryl members, -S (O) tR7, -S (O) 2NR7R8, -S (O) 2OR7, -NO2, - (CR5R6) qNR7R8, - N (CR5R6) (CR5R6) qNR7R8, -OR7, - O (CR5R6) (CR5R6) qOR7, -O (CR5R6) (CR5R6) qR7, -CN, -C (O) R7, -OC (O) R7, -O (CR5R6) qR7, -NR7C (O) R8, - (CR5R6) qC (O) OR7, - (CR5R6) qNR7R8, -C (> = NR7) NR7R8, -NR7C (O) NR7R8, -NR7S (O) 2R8 and - (CR5R6) qC (O) NR7R8; wherein each hydrogen in said C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic, and 5-6 membered heteroaryl optionally may be substituted for independently with halogen, -OH, -NH2, -S (O) tR9, -S (O) 2NR9R10, -S (O) 2OR9, -NO2, -OR9, -CN, -C (O) R9, - OC (O) R9, -NR9C (O) R10, -C (O) OR9, -C (> = NR9) NR9R10, -NR9C (O) NR9R10, -NR9S (O) 2R10 or -C (O) NR9R10; R3 and R4 are each independently selected from hydrogen, C1-C6 alkyl and C3-C6 cycloalkyl, wherein each hydrogen in C1-C6 alkyl and C3-C6 cycloalkyl may optionally be independently substituted with halogen, -OH, -NH2, -S (O) tR9, -S (O) 2NR9R10, -S (O) 2OR9, -NO2, -CN, -OR9, -C (O) R9, - OC (O) R9, -NR9C ( O) R10, -C (O) OR9, -C (> = NR9) NR9R10, -NR9C (O) NR9R10, -NR9S (O) 2R10 or -C (O) NR9R10; each R5 and R6 is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic, 5-heteroaryl -6 members, -OH, -NH2, -S (O) tR9, -S (O) 2NR9R10, -S (O) 2OR9, -NO2, -CN, -OR9, -C (O) R9, -OC ( O) R9, - NR9C (O) R10, -C (O) OR9, -C (> = NR9) NR9R10, -NR9C (O) NR9R10, -NR9S (O) 2R10 and -C (O) NR9R10; wherein each hydrogen in said C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic, and 5-6 membered heteroaryl optionally may be substituted for independently with halogen, -OH, -NH2, -S (O) tR9, -S (O) 2NR9R10, -S (O) 2OR9, -NO2, -CN, -OR9, -C (O) R9, -OC (O) R9, -NR9C (O) R10, - C (O) OR9, -C (> = NR9) NR9R10, -NR9C (O) NR9R10, -NR9S (O) 2R10 or -C (O) NR9R10; each R7 and R8 is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic and 5-heteroaryl -6 members, wherein each hydrogen in said C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic and 5-6 membered heteroaryl optionally can be independently substituted with halogen, -OH, -NH2, -S (O) tR9, -S (O) 2NR9R10, -S (O) 2OR9, -NO2, -OR9, -CN, - C (O) R9 , -OC (O) R9, -NR9C (O) R10, -C (O) OR9, -C (> = NR9) NR9R10, -NR9C (O) NR9R10, -NR9S (O) 2R10 or -C (O) NR9R10; each R9 and R10 is independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C12 aryl, 3-12 membered heteroalicyclic and 5-6 membered heteroaryl; m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; p is 0,1,2, 3 or 4; each q is independently Q, 1, 2 or 3; each r is independently 0, 1, 2 or 3; and each t is independently 0, 1 or 2; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2012-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 90.