abstract |
An isolated protein complex in the form of a synthetic chimeric protein, comprising an amino acid sequence of: (i) a growth factor, or at least one domain of said growth factor that is capable of binding to a growth factor receptor related; and (ii) one or more fibronectin (III) type III domains, wherein the one or more FN type III domains consists of amino acids 1266-1536 of the FN sequence set forth in SEQ ID NO: 1 , or amino acids 1447-1536 of the FN sequence set forth in SEQ ID NO: 1, or amino acids 1173-1536 of the FN sequence set forth in SEQ ID NO: 1, where one or more type III domains of FN comprise an integrin binding domain. |