| abstract |
A solid oral immediate release dosage form comprising a plurality of particles, each particle comprising: (i) an active agent and (ii) a material that is sensitive to acidic pH; wherein the plurality of particles is dispersed in a matrix comprising a gelling agent selected from the group consisting of pregelatinized starch, hydroxyethylcellulose, guar gum, xanthan gum, alginate, carrageenan and mixtures thereof and where the dosage form releases at least about 70% of the active agent at 45 minutes as measured by in vitro dissolution in a USP 2 Apparatus (paddle) at 50 rpm in 500 ml of 0.1 N HCl at 37 ° C. |