| abstract |
An asymmetric interfering RNA duplex molecule consisting of: a non-coding chain, consisting of 19-23 nucleotides, in which the non-coding chain contains a 3 'and a 5' protrusion, and in which the 3 'protrusion it consists of RNA nucleotides, and a coding chain, consisting of 14-17 nucleotides, in which the coding chain is at least 70% complementary to the non-coding chain, in which the non-coding chain is at least 70 % complementary to a target mRNA; and in which the non-coding chain and the coding chain form a double stranded region of 14, 15, 16 or 17 nucleotide base pairs |