| abstract |
Cells derived from umbilical cord tissue for the preservation of motor neuron function in patients with amyotrophic lateral sclerosis, when cells derived from umbilical cord tissue can be isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion of the culture, they have the potential to differentiate into cells of other phenotypes, they can undergo at least 40 duplications, and they have the following characteristics: (a) express each of CD 10, CD 13, CD44, CD73, CD90 , PDGFR-alpha, PD-L2 and HLA-A, B, C; (b) do not express any of CD31, CD34, CD45, CD80, CD86, CD117, CD141, CD 178, B7-H2, HLA-G, or HLA-DR, DP, DQ; and (c) have a higher expression of interleukin-8; reticulon 1; and chemokine receptor ligand (CXC motif) ligand 3, relative to that of a human cell, which is a fibroblast, a mesenchymal stem cell, or a bone iliac crest marrow cell. |