| abstract |
A stable pharmaceutical composition of curcumin comprising oil, solvent, surfactant and, optionally, antioxidant, the proportion of the oil being in relation to the solvent, of the surfactant with respect to the solvent and of the surfactant with respect to curcumin in the range of 0.83 at 10, from 1 to 60 and from 3 to 15, respectively, with curcumin in the range of 2 to 20% w / w, in which (i) the oil is selected from: (1) fractionated coconut oil, triglyceride caprylic / capric or an oil containing fatty acid triglycerides, preferably medium chain fatty acid triglycerides; (2) isopropyl myristate, isopropyl palmitate, ethyl linoleate or an oil containing ethyl oleate esters of fatty acids and monovalent alkanols; (3) propylene glycol dicaprilate, propylene glycol dilaurate or an oil containing diesters of propylene glycol fatty acids; (ii) the surfactant is selected from polysorbate, vitamin E TPGS and Cremophor®; and (iii) the solvent is selected from glycerol, polyethylene glycol, glycerol, polypropylene glycol, propylene glycol, glycerin, N-methyl-2-pyrrolidone and ethyl alcohol or mixture thereof. |