http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2615268-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4741 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-08 |
| filingDate | 2013-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a88ab529ef65364d64c830cf7ca03bf0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89b8fea71f9f474816dd8b5108ddd930 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf27ca75918bbd7cb97f4c8e9818c77b |
| publicationDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2615268-T3 |
| titleOfInvention | Enediine compounds, conjugates thereof and uses and methods for it |
| abstract | A compound having a structure represented by formula (I), ** Formula ** in which R0 is NHR1a, NHC (> = O) OR1b, NHC (> = O) NHR1b, OC (> = O) NHR1b, (CH2) 1-4NHR1a, F, Cl, Br, OR1a or SR1b; R1a is H, C1-C6 alkyl, (CH2) nNH2, C (> = O) (CH2) nNH2, C (> = O) CHR8NH2 or C (> = O) R9NH2; ** Formula ** R1b is H, C1-C6 alkyl, (CH2) nNH2; R2 is H, R10, C (> = O) R10 or C (> = O) OR10; R3 is H or C1-C6 substituted or unsubstituted alkyl; R4 is OH, SH, NH2, OR10, SR10, NHR10, N (R10) 2, NHC (> = O) OR10, OC (> = O) NHR1b, OC (> = O) R10, SC (> = O) R10 or NHC (> = O) R10; R5 is OH, SH, NH2, OR10, SR10, NHR10, N (R10) 2, NHC (> = O) OR10, OC (> = O) NHR1b, OC (> = O) R10, SC (> = O) R10 or NHC (> = O) R10; R6 is H or C1-C6 substituted or unsubstituted alkyl; or R5 and R6 combine to form> = O; R7 is OH, SH, NH2, OR10, SR10, NHR10, N (R10) 2, NHC (> = O) OR10, OC (> = O) NHR1b, OC (> = O) R10, SC (> = O) R10 or NHC (> = O) R10; R8 is the rest of the side chain of an α-amino acid selected from the group consisting of alanine, arginine, asparagine, aspartic acid, γ-carboxyglutamic acid, citrulline, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, norleucine, norvaline, ornithine, phenylalanine, serine, threonine, tryptophan, tyrosine and valine; R9 is substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, substituted or unsubstituted alkylarylene, substituted or unsubstituted cycloalkylene or substituted or unsubstituted heterocycloalkylene; each R10 is independently substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein the substituents of the substituted moieties are independently selected from each other of alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloaliphatic, heterocycloaliphatic, halo, haloalkyl, hydroxyl, hydroxyalkyl, cyano, nitro, alkoxy, -O (hydroxyalkyl), -O (haloalkyl), -O (cycloalkyl), -O (heterocycloalkyl), -O (aryl), alkylthio, arylthio,> = O,> = NH,> = N (alkyl),> = NOH,> = NO (alkyl ), -C (> = O) (alkyl), -C (> = O) H, -CO2H, -C (> = O) NHOH, -C (> = O) O (alkyl), - C (> = O) O (hydroxyalkyl), -C (> = O) NH2, -C (> = O) NH (alkyl), -C (> = O) N (alkyl) 2, -OC (> = O) ( alkyl), - OC (> = O) (hydroxyalkyl), -OC (> = O) O (alkyl), -OC (> = O) O (hydroxyalkyl), -OC (> = O) NH2, -OC ( > = O) NH (alkyl), - OC (> = O) N (alkyl) 2, azido, -NH2, -NH (alkyl), -N (alkyl) 2, -NH (aryl), -NH (hydroxyalkyl ), -NHC (> = O) (alkyl), - NHC (> = O) H, -NHC (> = O) NH2, -NHC (> = O) NH (alkyl), -NHC (> = O) N (alkyl) 2, -NHC (> = NH) NH2, -OSO2 (alkyl), -SH, -S (alkyl), -S (aryl), -S (cycloalkyl), -S (> = O) alkyl , -SO2 (alkyl), -SO2NH2, -SO2NH (alq uyl) and -SO2N (alkyl) 2; and n is 2, 3, 4, 5 or 6; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2012-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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