http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2615180-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f07ba5e7ff356b7eda43fdfc20eef4b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa5a331b4d3906bbee128126b00f0688 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9658f29dab8badc3559b79218f3440f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2810-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14133 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-025 |
| filingDate | 2008-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d5f6c6c9e8444fb4c52f592318a055a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f63d7da1e197792e8b3a14cbf5561478 |
| publicationDate | 2017-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2615180-T3 |
| titleOfInvention | Methods and compositions for the treatment of brain diseases |
| abstract | A modified adeno-associated virus (AAV) capsid protein, which comprises a targeting peptide, wherein the targeting peptide is 3 to 10 amino acids in length; and wherein: (i) the modified AAV capsid comprising the targeting peptide directs an AAV to the vascular endothelium of the wild-type brain, and the targeting peptide is TLH (SEQ ID NO: 3), or QSXY (SEQ ID NO: 4), PYFPSLS (SEQ ID NO: 5), YAPLTPS (SEQ ID NO: 6), PLSPSAY (SEQ ID NO: 7), DSPAHPS (SEQ ID NO: 8), GTPTHPS (SEQ ID NO: 9) , PDAPSNH (SEQ ID NO: 10), TEPHWPS (SEQ ID NO: 11), SPPLPPK (SEQ ID NO: 12), SPKPPPG (SEQ ID NO: 13), NWSPWDP (SEQ ID NO: 14), DSPAHPS (SEQ ID NO: 15), GWTLHNK (SEQ ID NO: 16), KIPPTLH (SEQ ID NO: 17), ISQTLHG (SEQ ID NO: 18), QSFYILT (SEQ ID NO: 19), or TTQSEYG (SEQ ID NO: 20) , as expressed in an amino to carboxy orientation or in a carboxy to amino orientation; or ~ (ii) the modified AAV capsid comprising the targeting peptide directs an AAV to the vascular endothelium of the diseased brain, the targeting peptide being LXSS (SEQ ID NO: 21), or SIXA (SEQ ID NO: 23), MLVSSPA (SEQ ID NO: 24), LPSSLQK (SEQ ID NO: 25), PPLLKSS (SEQ ID NO: 26), PXKLDSS (SEQ ID NO: 27), AWTLASS (SEQ ID NO: 28), WPFYGTP (SEQ ID NO : 29), GTFPFLG (SEQ ID NO: 30), GQVPFMG (SEQ ID NO: 31), ANFSILA (SEQ ID NO: 32), GSIWAPA (SEQ ID NO: 33), SIAASFS (SEQ ID NO: 34), or GMNAFRA (SEQ ID NO: 41), as expressed in an amino to carboxy orientation or in a carboxy to amino orientation. |
| priorityDate | 2007-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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