http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2614885-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3166d2820b5872ab84d235e5fae1d45 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 |
| filingDate | 2013-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd1701f4fd11e00dfba98965a2362ef4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15bbfd419362f86cb047c146d83fa0e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_285b76fa82381c336b586857c2125ca6 |
| publicationDate | 2017-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2614885-T3 |
| titleOfInvention | Substituted derivatives of phthalazin 1 (2H) one as selective inhibitors of poly (ADP ribose) polymerase 1 |
| abstract | Compound having the structure of the general formula (I) ** Formula ** in which R1 in each case is independently selected from H, halogen, or the groups selected from (C1-C12) alkyl, haloalkyl, cycloalkyl , alkylthio or the alkyl group (OSO2), in which each of these groups is optionally further substituted with suitable substituents selected from hydroxyl, oxo, halogen, thio, nitro, amino, alkyl, alkoxy, haloalkyl and haloalkoxy groups; R 'in each case is independently selected from halogen, alkyl, alkoxy, hydroxyl, haloalkyl, haloalkoxy, cyano, thioalkyl, cycloalkyl groups; m> = 1-4; L> = -O, -S, -NH; n> = 0-4; R2 is selected from substituent groups consisting of hydrogen atom, hydroxyl, alkyl, cycloalkyl, oxo, C (O) OR5, -C (O) R5 or -C (O) NR6R7, wherein said alkyl and cycloalkyl groups are further substituted with one or more substituents selected from halogen, hydroxyl, alkyl or alkoxy groups; R3 and R4 are each independently selected from a hydrogen atom, alkyl, hydroxyl, alkoxy, cycloalkyl, -C (O) OR5, -OC (O) R5, -O (CH2) pC (O) OR5 , -C (O) R5, -NHC (O) R5, -NR6R7, -OC (O) NR6R7 or -C (O) NR6R7, or alternatively, R3 and R4 together form an oxo group; each of the atoms of the ring "D" and "E" is independently selected from atoms of C or N; "D" and "E" are connected to each other to form a 5-member "X" ring, wherein "X" is selected from heterocyclyl and heteroaryl, wherein heterocyclyl and heteroaryl are substituted with one or more suitable substituents selected from hydrogen, cyano, halogen, hydroxyl, oxo, optionally substituted groups selected from alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, benzyl, OR5, -C (O) OR5, -OC (O) R5, -O (CH2 ) pC (O) OR5, C (O) R5, S (O) qR5, -NHC (O) R5, NR6R7, -OC (O) NR6R7 or -C (O) NR6R7, and in which the alkyl group, cycloalkyl, heterocyclyl, aryl, heteroaryl or benzyl can each be, independently, also substituted with one or more substituents selected from the alkyl, halogen, hydroxyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, oxo groups, - C (O) OR5, -OC (O) R5, -O (CH2) pC (O) OR5, -C (O) R5, S (O) qR5, -NHC (O) R5, NR6R7, -OC (O ) NR6R7 or -C (O) NR6R7; R5 in each case is independently selected from a hydrogen atom, optionally substituted groups selected from alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl groups, in which the optional substituents are selected from alkyl, halogen, hydroxyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxylic acid or carboxylic acid ester; each of R6 or R7 in each case is independently selected from H, optionally substituted groups selected from alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl groups, in which the optional substituents are independently selected from alkyl , halogen, hydroxy, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxylic acid or carboxylic acid ester; or R6 or R7 are joined together with the nitrogen atom to form a heterocyclyl ring; wherein said heterocyclyl ring contains one or more heteroatoms selected from N, O, S (O) q, q is 0, 1 or 2 and p is 0, 1 or 2. |
| priorityDate | 2012-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 231.