| abstract |
A compound having the formula ** Formula ** a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein n represents an integer that is 1; m represents an integer that is 0 or 1; R1 and R2 each independently represent C1-4alkyl; or R1 and R2 taken together with the carbon atom to which they are attached form a C3-6 cycloalkyl; R3 represents a monovalent radical having one of the following formulas ** Formula ** wherein said monovalent radical may optionally be substituted with one or when possible two or three substituents selected from the group consisting of C1-4alkyl, C1-alkyloxy 4, phenyl, halo, oxo, carbonyl, 1,3-dioxolyl, or hydroxy; R4 represents hydrogen; Q represents C3-8 cycloalkyl, Het1 or Ar2, wherein said C3-8 cycloalkyl, Het1 or Ar2 are optionally substituted with one or when possible more substituents selected from halo, C1-4 alkyl, C1-4 alkyloxy, hydroxy, nitro , Het4, phenyl, phenyloxy, (C1-4) alkyloxy -carbonyl, hydroxycarbonyl, NR5R6, C1-4 alkyloxy substituted with one or when possible two or three substituents each independently selected from C1-4 alkyl, hydroxycarbonyl, Het2 or NR7R8 , C2-4 alkenyl substituted with a substituent selected from phenyl (C1-4) alkyl-oxycarbonyl, (C1-4) alkyloxy -carbonyl, hydroxycarbonyl or Het5-carbonyl, and C1-4 alkyl substituted with one or where possible two or three substituents independently selected from halo, dimethylamino, trimethylamino, amino, cyano, Het6, Het7-carbonyl, (C1-4) alkyloxy -carbonyl or hydroxycarbonyl; R5 and R6 are each independently selected from hydrogen, C1-4alkyl, C1-4alkyloxy-C1-4alkyl, C1-4alkyloxycarbonyl, (C1-4alkyl) -carbonyl, alkyl ( C1-4) -carbonyl substituted with one or when possible two or three substituents each independently selected from halo, C1-4alkyl and C1-4alkyloxy or R5 and R6 each independently representing C1-4alkyl substituted with phenyl; R7 and R8 are each independently selected from hydrogen or C1-4alkyl; L represents C1-4 alkanediyl; Het1 represents a heterocycle selected from pyridinyl, piperinidyl, pyrimidinyl, pyrazinyl, piperazinyl, pyridacinyl, indolyl, isoindolyl, indolinyl, furanyl, benzofuranyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, benzothiophenyl, thiophenyl, 1,8-phenyl, naphthyridinyl, quinolinyl, 1,2,3,4-tetrahydro-quinolinyl, isoquinolinyl, 1,2,3,4-tetrahydro-isoquinolinyl, quinoxalinyl, quinazolinyl, phthalazinyl, 2H-benzopyranyl, 3,4-dihydro-2H-benzopyranyl, 2H-benzothiopyranyl, 3,4-dihydro-2H-benzothiopyranyl, or 1,3-benzodioxolyl; Het2 represents a monocyclic heterocycle selected from piperidinyl, pyridinyl, pyridacinyl, pyrimidinyl, pyrazinyl, piperazinyl, 2H-pyrrolyl, pyrrolyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolidinyl or morpholinyl, with Het2 being optionally substituted by one or when possible or more substituents each independently selected from hydroxy, C1-4alkyl, or C1-4alkyloxy; Het4 represents a monocyclic heterocycle selected from pyridacinyl, pyrimidinyl, pyrrolidinyl, pyrazinyl, piperazinyl, triazolyl, tetrazolyl or morpholinyl, said Het4 being optionally substituted with one or when possible two or more substituents each independently selected from hydroxy, carbonyl, C1- alkyl 4 or C1-4 alkyloxy; Het5 represents a monocyclic heterocycle selected from pyridacinyl, pyrimidinyl, pyrrolidinyl, pyrazinyl, piperazinyl, or morpholinyl, said Het5 being optionally substituted with one or when possible two or more substituents each independently selected from hydroxy, carbonyl, C1-4alkyl or C1-alkyloxy -4; Het6 represents a monocyclic heterocycle selected from pyridacinyl, pyrimidinyl, pyrrolidinyl, pyrazinyl, piperazinyl, or morpholinyl, said Het6 being optionally substituted with one or when possible two or more substituents each independently selected from hydroxy, carbonyl, C1-4alkyl or C1-alkyloxy -4; Het7 represents a monocyclic heterocycle selected from pyridacinyl, pyrimidinyl, pyrrolidinyl, pyrazinyl, piperazinyl, or morpholinyl, said Het7 being optionally substituted with one or when possible two or more substituents each independently selected from hydroxy, carbonyl, C1-4alkyl or C1-alkyloxy -4; Ar2 represents carbocyclic radicals containing one or more rings selected from the group consisting of phenyl, biphenyl, benzocyclobutenyl, benzocycloheptanyl, benzosuberenyl, indenyl, 2,3-dihydroindenyl, fluorenyl, 1,2-dihydronaphthyl, 5,6,7,8- tetrahydronaphthyl or naphthyl. |