http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2614050-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c851e729089df9a427027272fa290 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-353 |
| filingDate | 2014-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbed60a30fb16396fa399e8bd6b4bdb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43771c7851db3be05c637d8a13eb9c4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96a2749e26d4f323dde0c2fbedfd5f4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8a68e48d05afdbd55d147e2c41f800e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_264131e3319f9456d5a72b81bcee655e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d65a0b28d1e157c42060385e04e11f67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_252eed1970a1591f4bf70b6af1ea6c72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84710855611670102a0bf4ac9fc8df6d |
| publicationDate | 2017-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2614050-T3 |
| titleOfInvention | Chroman-6-yloxy-substituted cycloalkanes and their use as pharmaceuticals |
| abstract | A compound of formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any proportion, or a pharmaceutically acceptable salt thereof, ** Formula ** wherein Ar is phenyl which is unsubstituted or substituted with one or more the same or different R0 substituents; R0 is selected from the series consisting of halogen, (C1-C6) alkyl, cycloalkyl- (C3-C7), cycloalkyl- (C3-C7) - alkyl- (C1-C4), HO-, -alkyl- ( C1-C6) -O-, cycloalkyl- (C3-C7) -O- and cycloalkyl- (C3-C7) -alkyl- (C1-C4) -O-, and two R0 groups attached to adjacent ring carbon atoms in Ar, together with the carbon atoms that carry them, they can form a 5-membered to 7-membered monounsaturated ring comprising 0, 1 or 2 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted by one or more same or different substituents selected from the series consisting of fluoro and (C1-C4) -alkyl; R1 is hydrogen or one or more same or different substituents selected from the series consisting of fluoro and (C1-C4) alkyl; R2 is selected from the series consisting of hydrogen, (C1-C6) -alkyl, HO-,-(C1-C6) -alkyl- -O-,-(C1-C6) -alkyl- -C (O) - O- , phenyl-C (O) -O-, Het1-C (O) -O-, R5-N (R6) -, R7-C (O) -N (R8) -, R7-S (O) 2- N (R8) -, R9-N (R10) -C (O) -N (R8) - and R5-N (R6) -C (O) -, where alkyl- (C1-C6) is unsubstituted or substituted with one or more same or different R20 substituents; R3 is selected from the series consisting of hydrogen and (C1-C6) -alkyl, wherein (C1-C6) -alkyl is unsubstituted or substituted with one or two same or different substituents selected from the series consisting of cycloalkyl - (C3-C7), phenyl, HO- and alkyl- (C1-C4) -O-; or the groups R2 and R3 together are oxo: R4 is hydrogen or one or more same or different substituents selected from the series consisting of halogen, (C1-C4) -alkyl and (C1-C4) -alkyl-O-; R5 and R6 are independently selected from each other, from the series consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C7) cycloalkyl, (C6-C10) bicycloalkyl) , phenyl, Het1 and Het2, wherein the (C1-C6) alkyl is unsubstituted or substituted with one or more of the same or different R20 substituents and (C3-C7) cycloalkyl, (C6-C10) cycloalkyl and Het2 are all unsubstituted or substituted with one or more the same or different R21 substituents, and phenyl and Het1 are all unsubstituted or substituted with one or more the same or different R22 substituents; or the groups R5 and R6, together with the nitrogen atom that carries them, form a saturated or partially unsaturated, monocyclic or bicyclic, 4-membered to 7-membered heterocycle that, in addition to the nitrogen atom that carries R5 and R6, comprises 0 or 1 additional ring hetero atom selected from the series consisting of nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted by one or more same or different R21 substituents; R7 is selected from the series consisting of (C1-C6) alkyl, (C3-C7) cycloalkyl, phenyl, Het1 and Het2, wherein (C1-C6) alkyl is unsubstituted or substituted by one or more substituents The same or different R20, and (C3-C7) cycloalkyl and Het2 are all unsubstituted or substituted with one or more the same or different R21 substituents, and phenyl and Het1 are all unsubstituted or substituted with one or more the same or more R22 substituents different; R8 is selected from the series consisting of hydrogen and (C1-C4) alkyl; R9 is selected from the series consisting of (C1-C6) -alkyl, (C3-C7) -cycloalkyl, (C3-C7) -cycloalkyl-(C1-C4) -alkyl, phenyl-(C1-C4) -alkyl and Het1-alkyl- (C1-C4); R10 is selected from the series consisting of hydrogen, (C1-C6) -alkyl, (C3-C7) -cycloalkyl, (C3-C7) -cycloalkyl- (C1-C4) -alkyl, phenyl-(C1-) -alkyl- C4) and Het1-alkyl- (C1-C4); R20 is selected from the series consisting of R24, fluoro, HO-, oxo, -alkyl- (C1-C6) -O-, -cycloalkyl- (C3-C7) -O-, R30-C (O) -O -, R30-NH-C (O) -O-, HO-S (O) 2-O-, (HO) 2P (O) -O-, (HO) 2P (O) -O-CH2-OC ( O) -O-, (C1-C6) -alkyl-S (O) n-, cycloalkyl- (C3-C7) -S (O) n- R31-N (R32) -, R33-C (O) - N (R32) -, alkyl- (C1-C6) -S (O) 2-N (R32) -, R31-N (R32) -C (O) -, R34-OC (O) - and R31-N (R32) -S (O) 2-; R21 is selected from the series consisting of (C1-C4) -alkyl, HO-(C1-C4) -alkyl, R31-N (R32)-(C1-C4) -alkyl, R34-OC (O) -alkyl - (C1-C4), R24, fluoro, HO-, oxo, alkyl- (C1-C6) -O-, -cycloalkyl- (C3-C7) -O-, R30-C (O) -O-, R30 -NH-C (O) - O-, HO-S (O) 2-O-, (HO) 2P (O) -O-, (HO) 2P (O) -O-CH2-OC (O) - O-, (C1-C6) -alkyl-S (O) n-, -cycloalkyl- (C3-C7) -S (O) n-, R31- N (R32) -, R33-C (O) -N (R32) -, alkyl- (C1-C6) -S (O) 2-N (R32) -, R31-N (R32) -C (O) -, R34-OC (O) - and R31-N ( R32) -S (O) 2-; R22 is selected from the series consisting of halogen, (C1-C4) -alkyl, HO-(C1-C4) -alkyl-, (C3-C7) -cycloalkyl, HO-, oxo,-(C1-C6-alkyl) ) -O-, -cycloalkyl- (C3-C7) -O-, HO-S (O) 2-O-, (HO) 2P (O) -O-, (HO) 2P (O) -O-CH2 -OC (O) -O-, alkyl- (C1-C6) -S (O) n-, -cycloalkyl- (C3-C7) -S (O) n-, R31-N (R32) -, R33- C (O) -N (R32) -, R33-OC (O) N (R32) -, alkyl- (C1-C6) -S (O) 2- N (R32) -, NC-, R33-C ( O) -, R31-N (R32) -C (O) -, R34-OC (O) - and R31-N (R32) -S (O) 2-; R24 is a 3-membered to 10-membered monocyclic or bicyclic ring that is saturated, partially unsaturated, or aromatic and comprises 0, 1, 2, 3, or 4 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted with one or more same or different R22 substituents; R30 and R33 are independently selected from each other in the series consisting of (C1-C6) -alkyl, (C3-C7) -cycloalkyl, (C3-C7) -cycloalkyl- (C1-C4) -alkyl, phenyl- (C1-C4) -alkyl and Het1-(C1-C4) -alkyl; R31 and R32 are independently selected from each other from the series consisting of hydrogen, (C1-C6) alkyl, cycloalkyl (C3-C7), cycloalkyl- (C3-C7) -alkyl- (C1-C4), phenyl-C1- C4-alkyl- and Het1-C1- C4-alkyl, or the groups R31 and R32, together with the nitrogen atom carrying them, form a monocyclic saturated 4-membered to 7-membered heterocycle that , in addition to the nitrogen atom carried by R31 and R32, comprises 0 or 1 additional ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted by one or more same or different substituents selected from the series consisting of fluorine and (C1-C4) -alkyl; R34 is selected from the series consisting of hydrogen, (C1-C6) -alkyl, (C3-C7) -cycloalkyl, (C3-C7) -cycloalkyl-(C1-C4) -alkyl-, phenyl-(C1-) -alkyl C4) and Het1-alkyl- (C1-C4); Het1 is a 5-membered or 6-membered monocyclic aromatic heterocycle comprising 1, 2 or 3 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, which is unsubstituted or substituted by one or more equal substituents or different selected from the series consisting of halogen, (C1-C4) -alkyl and (C1-C4) -alkyl-O-, unless otherwise specified; Het2 is a 4-membered to 10-membered monocyclic or bicyclic saturated or partially unsaturated heterocycle comprising 1 or 2 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur; n is selected from the series consisting of 0, 1 and 2, where all the numbers n are independent of each other; p and q are independently selected from one another in the series consisting of 0 and 1; wherein all phenyl groups are unsubstituted or substituted with one or more same or different substituents selected from the series consisting of halogen, (C1-C4) -alkyl and-(C1-C4) -alkyl-O-, unless that something else be specified; wherein all cycloalkyl and bicycloalkyl groups, independently of any other substituents that may be present on a cycloalkyl or bicycloalkyl group, may be substituted with one or more same or different substituents selected from the series consisting of fluorine and (C1-) alkyl. C4); wherein all alkyl groups, independently of any other substituents that may be present on an alkyl group, may be substituted with one or more fluorine substituents. |
| priorityDate | 2013-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 828.