abstract |
An amino acid having the formula (A): ** Formula ** in which: L1 and L2 are independently a straight chain alkylene of 3 to 7 carbon atoms; Ra is hydrogen; aliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; heteroaliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; cyclic or acyclic acyl, substituted or unsubstituted; or Ra is a suitable amino protecting group; each case of Rc is, independently, hydrogen; aliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; heteroaliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; cyclic or acyclic acyl, substituted or unsubstituted; substituted or unsubstituted hydroxyl; substituted or unsubstituted thiol; substituted or unsubstituted amino; cyano; isocyanate; halo; or nitro; Re is hydrogen, cyclic or acyclic aliphatic, branched or unbranched, substituted or unsubstituted; heteroaliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; substituted or unsubstituted acyl; a resin; a suitable hydroxyl, amino or thiol protecting group; Rf is hydrogen; aliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; heteroaliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; substituted or unsubstituted acyl; a resin; a suitable amino protecting group; a label optionally linked by a linker, wherein the linker is selected from cyclic or acyclic alkylene, branched or unbranched, substituted or unsubstituted; cyclic or acyclic alkenylene, branched or unbranched, substituted or unsubstituted; cyclic or acyclic alkynylene, branched or unbranched, substituted or unsubstituted; cyclic or acyclic heteroalkylene, branched or unbranched, substituted or unsubstituted; cyclic or acyclic heteroalkenylene, branched or unbranched, substituted or unsubstituted; cyclic or acyclic heteroalkylene, branched or unbranched, substituted or unsubstituted; substituted or unsubstituted arylene; substituted or unsubstituted heteroarylene; or substituted or unsubstituted acylene; or Rf and Ra together form a substituted or unsubstituted 5- or 6-membered heterocyclic or heteroaromatic ring; each case of x is, independently, an integer between 0 and 3; and in which it corresponds to a double or triple bond. |