abstract |
A recombinant NRG-2 polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 2 for use in the treatment or prophylaxis of a pathophysiological condition in a subject, wherein the recombinant NRG-2 polypeptide increases mitogenesis, survival, growth. or differentiation of a muscle cell, where the muscle cell expresses an erbB receptor that is selective for the NRG-2 polypeptide, and where the pathophysiological condition is selected from the group consisting of cardiomyopathy, ischemic damage, cardiac trauma and insufficiency. cardiac |