| abstract |
A system for the heterologous expression of a monoclonal antibody (AcMc) or of an antigen binding fragment or a derivative thereof, said system comprising a) at least one ciliated host cell, and b) incorporated, in said ciliated host cell, at least one molecule of a heterologous nucleic acid encoding said monoclonal antibody, or a fragment or derivative thereof, and the system further comprises a signaling sequence operatively linked to said nucleic acid molecule, said signaling sequence being responsible for the secretion of the monoclonal antibody, or fragment thereof, encoded by said nucleic acid molecule, in the extracellular medium, in which the ciliated is a member of the Tetrahymenidae family, and in which the antigen binding derivative is at least one selected from the group consisting of * scFv, or * bispecific, trypecific or spec antibody constructs superiority. |