http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2609578-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_872dd7cd609eb2a937dcfd303d521798 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2012-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c287c5c82394c52f7b309536f52724e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6ee4cb8642d544245932523a5b95383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c1bf780d51bcc74965b4ec0ebff50b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9792a8ee70812ddf5f4ffbb3f88e5117 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d83ae6df4942f5366f0eb5cb06a2daa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc07919c1b6de31b2bd28886668e7ef5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26b924acd37c13550c2aa63cfeba71e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d288e6fdbd774621a9f0f0ab7d6fc69b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bca6e02471b8ca4e2eba5c66a9284267 |
| publicationDate | 2017-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2609578-T3 |
| titleOfInvention | Amino-quinolines as kinase inhibitors |
| abstract | Compound according to Formula (I): ** Formula ** in which: R1 is H, -SO2 (C1-C4 alkyl), -CO (C1-C4 alkyl) or (C1-C4 alkyl); R2 is -SORa or -SO2Ra, in which Ra is a (C1-C6) alkyl, C3-C7 cycloalkyl, 4-7 membered heterocycloalkyl, aryl or heteroaryl group, optionally substituted in which: said (C1-alkyl) -C6) is optionally substituted with one or two groups each independently selected from the group consisting of cyano, hydroxyl, (C1-C6) alkoxy, (C1-C6) alkoxy (C2-C6) alkoxy, -CO2H, -CO2alkyl (C1-C4), -SO2 (C1-C4 alkyl), -CONH2, -CONH (C1-C4 alkyl), -NHC (> = O) (C1-C4 alkyl), -CON (C1-C4 alkyl) ( C1-C4 alkyl), -N (C1-C4 alkyl) (C (> = O) (C1-C4 alkyl)), -SO2NH2, -SO2NH (C1-C4 alkyl), -NHSO2 (C1-C4 alkyl), -SO2N (C1-C4 alkyl) (C1-C4 alkyl), -N (C1-C4 alkyl) (SO2 (C1-C4 alkyl)), amino, (C1-C4 alkyl) amino-, (C1-C4 alkyl) (C1-C4 alkyl) amino-, C3-C7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 9-10 member heteroaryl, 4-7 member heterocycloalkyl and (phenyl) (C1-C4 alkyl) amino-, in which said C3-C7 cycloalkyl, phenyl, (phenyl) (C1-C4 alkyl) amino-, heteroa 5-6 membered ryl, 9-10 membered heteroaryl or 4-7 membered heterocycloalkyl is optionally substituted with 1-3 groups each independently selected from the group consisting of halogen, -CF3, (C1-C4) alkyl, hydroxyalkyl (C1-C4) and alkoxy (C1-C4), said cycloalkyl (C3-C7) or 4-7 membered heterocycloalkyl is optionally substituted with 1-3 groups each independently selected from the group consisting of halogen, -CF3 , hydroxyl, amino, (C1-C4 alkyl) amino-, (C1-C4 alkyl) (C1-C4 alkyl) amino-, (C1-C4) alkyl, phenylalkyl (C1-C4) -, hydroxyalkyl (C1-C4) -, oxo, (C1-C4) alkoxy and (C1-C4) alkoxy (C2-C4) alkoxy -, and said aryl or heteroaryl is optionally substituted with 1-3 groups each independently selected from the group consisting of halogen, -CF3, hydroxyl, amino, (C1-C4) alkyl, phenylalkyl (C1-C4) -, hydroxyalkyl (C1-C4) - and (C1-C4) alkoxy, and wherein said heteroaryl is a 5-6 heteroaryl members or a 9-10 membered heteroaryl, and any of said 4-7 membered heterocycloalkyl contains a heteroatom selected from the group consisting of N, O and S, any of said 5-6 membered heteroaryl contains a heteroatom selected from the group consisting of N, O and S and optionally also contains one or two nitrogen atoms, and any of said 9-10 membered heteroaryl contains a heteroatom selected from the group consisting of N, O and S and optionally also contains 1 , 2 or 3 nitrogen atoms; R3 is halogen, hydroxy, (C1-C4) alkyl -, (C1-C4) alkoxy -, halo (C1-C4) alkyl -, (C1-C4) haloalkoxy -, (C1-C4) alkoxy (C1-C6) alkyl -, haloalkoxy (C1-C4) alkyl (C1-C6) -, alkoxy (C1-C4) alkoxy (C2-C6) -, haloalkoxy (C1-C4) alkoxy (C2-C6) -, hydroxyalkyl (C1-C4) -, hydroxyalkoxy (C2-C6) -, cyanoalkyl (C1-C4) -, cyanoalkoxy (C2-C6) - or cycloalkoxy (C3-C6) -, in which haloalkyl (C1-C4) -, haloalkoxy (C1- C4) -, (C1-C4) haloalkoxy (C1-C6) alkyl - or (C1-C4) haloalkoxy (C2-C6) alkoxy - contains 2 or 3 halo atoms and in which the cycloalkyl (C3-C6) moiety from the cycloalkoxy group (C3-C6) -, is optionally substituted with a group selected from the group consisting of cyano, halo, hydroxyl, (C1-C6) alkoxy and (C1-C4) alkoxy (C2-C6) alkoxy; Z is phenyl or aryl (C1-C4) alkyl -, substituted with R4, R5, R6 and R7, in which: R4 is H, halogen, cyano, (C1-C4) alkyl, halo (C1-C4) alkyl, alkoxy ( C1-C4), phenoxy, phenylalkoxy (C1-C4), hydroxyl, hydroxyalkyl (C1-C4) - or aminocarbonyl, wherein the phenyl moiety of said phenoxy or phenylalkoxy (C1-C4) - is optionally substituted with 1-3 substituents each independently selected from the group consisting of halogen, -CF3, (C1-C4) alkyl and (C1-C4) alkoxy; and each of R5, R6 and R7 is independently selected from the group consisting of H, hydroxyl, halogen, -CF3, hydroxyalkyl (C1-C4), alkyl (C1-C4) and alkoxy (C1-C4); or Z is phenyl substituted with R8, R9 and R10, in which: R8 and R9 are located in adjacent atoms and taken together with the atoms to which they are attached form a 5-membered heterocyclic group containing 1, 2 or 3 heteroatoms each independently selected from the group consisting of N, O and S, a 5-membered heterocyclic group that is substituted with R11; wherein one of R10 or R11 is H, halogen, cyano, (C1-C4) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, phenoxy, phenylalkoxy (C1-C4), hydroxyl, hydroxyalkyl (C1 -C4) - or aminocarbonyl, wherein the phenyl moiety of said phenoxy or phenylalkoxy (C1-C4) is optionally substituted with 1-3 substituents each independently selected from the group consisting of halogen, -CF3, (C1-) alkyl C4) and (C1-C4) alkoxy; and the other of R10 or R11 is H, hydroxyl, halogen, haloalkyl (C1-C4), hydroxyalkyl (C1-C4), alkyl (C1-C4) or alkoxy (C1-C4); or Z is pyrazolyl, having the formula: ** Formula ** in which: R12 is methyl or trifluoromethyl (-CH3 or -CF3); R13 is H, methyl, hydroxymethyl or trifluoromethyl (-CH3, -CH2OH or -CF3); R14 is H or (C1-C3) alkyl; or R12 and R13, taken together with the atoms to which they are attached, form a 6-membered carbocyclic ring or heterocyclic ring substituted with R15 and R16, wherein the heterocyclic ring contains 1 nitrogen atom; wherein R15 and R16 are each independently selected from the group consisting of H, halogen, cyano, (C1-C4) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, phenoxy, phenylalkoxy (C1- C4), hydroxyl, hydroxyalkyl (C1-C4) - and aminocarbonyl, wherein the phenyl moiety of said phenoxy or phenylalkoxy (C1-C4) is optionally substituted with 1-3 substituents each independently selected from the group consisting of halogen , -CF3, (C1-C4) alkyl and (C1-C4) alkoxy; with the proviso that the compound is not N- (4-chloro-2-fluorophenyl) -7-methoxy-6 - [(2-methoxyethyl) sulfinyl] -4-quinolinamine or 3 - [[7-bromo-6- (methylsulfonyl) -4-quinolinyl] amino] -4-methylphenol; or a salt thereof. |
| priorityDate | 2011-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 263.