| abstract |
A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof: ** Formula ** where A is selected from ** Formula ** and where: X is selected from O, S , CH2, NRN1 where RN1 is selected from H, C1-4alkyl, -LA-NRA1RA2, -LA-ORA, where LA is C1-3alkylene and each RA is independently selected from H and C1-4alkyl; Y is selected from H, F and Cl; R1 is selected from H, F, cyclopropyl and -CH2-ZB, where ZB is selected from: H, F, Cl, Me, -CH> = CH2, heterocyclyl, -ORB1, -NRB1RB2, -LB1-ORB1A, - LB1-NRB1ARB1B, -LB1-RB1C, -O-LB2-ORB2A, -O-LB2-NRB2ARB2B, -O-LB2-RB2C, -NH-LB2-ORB2A, -NH-LB2-NRB2ARB2B AND -NH-LB2 wherein RB1 and RB2 are each independently H or C1-4alkyl, LB1 is C1-3alkylene, RB1A and RB1B are each independently H or C1-4alkyl and RB1C is heterocyclyl, and LB2 is C1-3alkylene, RB2A and RB2B are each independently H or C1-4alkyl and RB2C is heterocyclyl; R2 is selected from H, F, and Me; and R3 is selected from H, F, and Me. |