http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2609335-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2010-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_808e54902e5b6670fe69390923b355ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_168a8f256b55d9a3ce1f4b78c50ced46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61efa654c9bff85e2b884a1f16ff28b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_267f51ca7cd245d3e0470a72119b670c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5037c761a40d77ef07a772e29922730b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e30581b7819739c7239c49bf53de8ea9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d279816f272191b6bd83a2349fd658a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_531f890bf1d2fe1b89c402384ff097ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88f073f314d53b94ccf54ba817b9ba02 |
| publicationDate | 2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2609335-T3 |
| titleOfInvention | Quinazolines as inhibitors of potassium ion channels |
| abstract | A compound of formula (Ib) or (Ic) ** Formula ** or an enantiomer, a diastereomer, a tautomer or a salt thereof, in which: X is H, F, Cl, Br, I, C1- alkoxy 10, C1-10 haloalkyl, 4-12 membered heterocyclyl, -CO2R11 or -NR11R12; Y is H, F, Cl, Br, I, C1-10 alkoxy, C1-10 haloalkyl, 4-12 membered heterocyclyl, -CO2R11 or -NR11R12; Z is H, Cl, Br, I, C1-10 alkoxy, C1-10 haloalkyl, 4-12 membered heterocyclyl or -NR11R12; R11 and R12, at each occurrence, are independently selected from H, C1-10 alkyl, C1-10 haloalkyl, C3-10 cycloalkyl, C6-10 aryl, a 4-12 membered heteroaryl and a 4-12 membered heterocyclyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl can be optionally substituted with one or more R13 and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group that consists of N, S or O; R13a is independently H, -OH, F, Cl, Br, I, C1-10 alkyl, C2-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a heteroaryl of 4 with 12 members, a 4 to 12 membered heterocyclyl, a 4 to 12 membered heteroaryl-C1-10 alkyl, -CN, - (CH2) m-SO2R14, -NR14SO2R14, -CONR14R14, - (CH2) m-NR14SO2R14, - (CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, - SO2NR14CONR14R14, -NR14CO2R14, -CO2R14 or -NR14R14, wherein alkyl, cycloalkyl, alkenyl, alkoxy, the aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R13a-2 is independently H, -OH, F, Br, I, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a heteroaryl of 4 to 12 members, a 4 to 12 membered heterocyclyl, a 4 to 12 membered heteroaryl-C1-10 alkyl, - (CH2) m-SO2R14, -NR14SO2R14, -CONR14R14, - (CH2) m-SO2NR14R14, - (CH2 ) m- NR14SO2R14, - (CH3) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, - SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R, oN14al2, el14-al14-yl-yl-alRalR-1, al-alkyl14-al14-yl-yl-yl-yl-yl-al-1-yl-yl-al-alkyl-14-yl-alkyl-14-yl-alkyl-14-yl-alkyl-1 , the alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R13b is independently H, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a 4 to 12 membered heteroaryl , a 4 to 12 membered heterocyclyl, a 4 to 12 membered heteroaryl-C1-10 alkyl, -CN, - (CH2) m-SO2R14, -NR14SO2R14, - (CH2) m-NR14SO2R14, - (CH2) n- NR14SO2NR14R14, - NR14SO2NR14R14, -CO2NR14R14, -CONR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, - SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14 or -NR14CONR14R14, wherein alkyl, cycloalkyl, alkenyl, alkoxy, the aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R13b-2 is independently H, -OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a heteroaryl 4 to 12 members, a 4 to 12 membered heterocyclyl, a 4 to 12 membered heteroaryl-C1-10 alkyl, -CN, - (CH2) m-SO2R14, -NR14SO2R14, - (CH2) m-SO2NR14R14, - (CH2) m-NR14SO2R14, - (CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, - SO2NR14CONR14R14, -NR14CO2R14, -alkyl, al-alkyl2, el-alkyl, al-alkyl2, el-alkyl, al-alkyl2, el-alkyl2, el-alkyl2 the alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14b and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or OR; R13c is independently H, -OH, Cl, Br, I, C1-10 alkyl, C1-10 hydroxyalkyl, C1-10 cyanoalkyl, C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, aryl C6-10, a 4 to 12 membered heteroaryl, a 4 to 12 membered heterocyclyl, -CN, - (CH2) m-SO2R14, - (CH2) n-OCONR14R14, -NR14SO2R14, -CONR14R14, - (CH2) m - SO2NR14R14, - (CH2) m-NR14SO2R14, - (CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, - NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -NR14CO2R (NR14CO2R) -NR14CO2R (NR14CO2R) -NR14CO2R) NR14R14 or - NR14CONR14R14, wherein the cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R13c-2 is independently H, -OH, F; Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a 4 to 12 membered heteroaryl, a 4 to 12 heterocyclyl members, a 4 to 12-membered heteroaryl-C1-10 alkyl, -CN, - (CH2) m-SO2R14, -NR14SO2R14, -CONR14R14, - (CH2) m-SO2NR14R14, - (CH2) m-NR14SO2R14, - ( CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, - NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14 or -alkyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, allyl, alkylo the heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R13d is independently H, -OH, F, Cl, Br, I, C1-10 alkyl, C2-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a heteroaryl of 4 with 12 members, a 4 to 12 membered heterocyclyl, a 4 to 12 membered heteroaryl-C1-10 alkyl, -CN, - (CH2) m-SO2R14, -NR14SO2R14, -CONR14R14, - (CH2) m-NR14SO2R14, - (CH2) , the alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting in N, S or O; R13d-2 is independently H, -OH, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C1-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a heteroaryl of 4 12-membered, a 4 to 12-membered heterocyclyl, a 4 to 12-membered heteroaryl-C1-10 alkyl, -CN, - (CH2) m-SO2R14, -NR14SO2R14, -CONR14R14, - (CH2) m-SO2NR14R14, - (CH2) m-NR14SO2R14, - (CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, - NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R2, al14-ald, el14-ald, el14-ald, el14 , the alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R14, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, a 4-12 membered heteroaryl or a 4-12 membered heterocyclyl, wherein the alkyl, the cycloalkyl , aryl, heteroaryl and heterocyclyl may be optionally substituted with 0-3 R14a and heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O ; R14a, at each occurrence, is independently selected from F, Cl, Br, I, C1-10 alkyl, C1-10 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, a 4- to 12-membered heteroaryl, a 4-heterocyclyl to 12 members, -CN, -CO2H, - CO2R26, -OCONR24R24, -CO2NR24R24, -OCF3, -OR25, -CONR24R24, -SO2R24, -NR24R24 or C6-10 aryl-C1-10 alkyl, where heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R24, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, a 4 to 12 membered heteroaryl or a 4 to 12 membered heterocyclyl, wherein the alkyl, aryl , the heteroaryl and heterocyclyl may be optionally substituted with one or more R24a and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; or two R24 are taken together with the atoms to which they are attached forming a cyclic ring, wherein the cyclic ring may be optionally substituted with one or more R24a and optionally containing 1, 2, 3 or 4 heteroatoms independently selected from the group that consists of N, S or O; R24a, at each occurrence, is independently selected from F, Cl, Br, I, C1-10 alkyl, C1-10 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, a 4- to 12-membered heteroaryl, a 4-heterocyclyl 12-member, -CN, -CO2R25, - OCF3, -OR25, -CONR25R25, -NR25R25 or C6-10 aryl-C1-10 alkyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R25, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, a 4-12 membered heteroaryl or a 4-12 membered heterocyclyl, wherein the heteroaryl and heterocyclyl they consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; and R26, at each occurrence, is independently selected from C1-10 alkyl, C1-10 haloalkyl, C3-10 cycloalkyl, C6-10 aryl, a 4-12 membered heteroaryl or a 4-12 membered heterocyclyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; m is 0 to 4; and n is 1 to 4; with the proviso that X, Y, Z, R13a, R13b, R13d, R13a-2, R13b-2, R13c-2 and R13d-2 are not all H when R13c is - C (> = O) N (C2H4OCH3) 2, -SO2N (C2H4OH) 2. |
| priorityDate | 2009-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1150.