http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2608829-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef8d8a82fd7380682fc0828e58b5f89e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C243-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 |
| filingDate | 2012-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d04b2fb5f55267f0632201bdadd17970 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a69121afad8c6e827d4a657739688f81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97d2b9d3f8548c43d6d20a0fb4e87db7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a23343217803806c16e63b1ab35a1b3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28934a356b57ac489ff791fb4b5c1cd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d18d287fe6662d2eacde9f5aa1d76f8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1dda2722ac67c16cf827c9c349aa213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a23049811d2ea4521129d08f21e678e |
| publicationDate | 2017-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2608829-T3 |
| titleOfInvention | Tyrosine kinase inhibitors containing diarylacetylene hydrazide |
| abstract | A compound of formula (I), ** Formula * +, or pharmaceutically acceptable salts thereof, wherein; ring P and ring Q are independently selected from an aryl ring having 6 to 14 carbon atoms, or 5- to 14-membered heteroaryl ring, containing from one to four heteroatoms each independently selected from O, S and N, optionally substituted by one or more identical or different R3 radicals, provided that when ring Q is pyridyl then ring P is heteroaryl; R1 and R2 are independently selected from the group consisting of hydrogen, radical -C1-8alkyl, - C2-10alkenyl, -C2-12alkynyl, -C3-12cycloalkyl, -C3-12cycloalkylalkyl, C3-12 -cycloalkenyl, aryl, heteroaryl, arylalkyl and a heteroarylalkyl, in which the aryl ring contains 6 to 14 carbon atoms, and the heteroaryl ring contains a 5- to 14-membered ring system with one to four heteroatoms each independently selected from O, S and N, and are optionally substituted by one or more identical or different R3 radicals; X is selected from the group consisting of C> = O and C> = S; Y is C> = O; R3 is selected from the group consisting of halogen, -OH, -CN, -NO2, -N3, -C1-8-alkyl, -C3-12-cycloalkyl, - (C1-8-alkyl) -C3-12-cycloalkyl, -heterocycloalkyl containing 3 to 12 ring atoms having one or two heteroatoms each independently selected from O, S and N, group - (C1-8 alkyl) -heterocycloalkyl containing 3 to 12 ring atoms having one or two heteroatoms each independently selected from O, S and N, -O-C1-8alkyl, -O- C3-12 cycloalkyl, -O-aryl, -O-heteroaryl, -C1-8alkyl-O- C1-alkyl 8, -O-C1-8alkyl-O- C1-8alkyl, -O-C1-8alkyl-NH (C1-8alkyl), -O-C1-8alkyl-N (C1-8alkyl) 2, -O-C1-8alkyl- (heteroaryl), - C (O) - C1-8alkyl, -COOH, -C (O) NH2, -C (O) NH- C1-8alkyl, -C (O) N (C1-8alkyl) 2, - C (O) O- C1-8alkyl, - haloC1-8alkyl, -C2-10alkenyl, -C2-12alkynyl, -OC (O) -NH2, -OC ( O) -NH (C1-8 alkyl), -OC (O) -N (C1-8 alkyl) 2, -NH2, -NH (C1-8 alkyl), -N (C1-8 alkyl) 2, -NH -SO2- C1-8 alkyl, -N (C1-8 alkyl ) -SO2- C1-8 alkyl, -NH- C (O) - (C1-8 alkyl), -N (C1-8 alkyl) -C (O) - (C1-8 alkyl), -NH-C ( O) O- C1-8 alkyl, -N (C1-8 alkyl) -C (O) O- C1-8 alkyl, - NH-C (O) -NH2, -NH-C (O) -NH (alkyl C1-8), -N (C1-8 alkyl) -C (O) -NH (C1-8 alkyl), -N (C1-8 alkyl) -C (O) -N (C1-8 alkyl) 2, -NH-C (O) -NH-SO2- C1-8 alkyl, -N (C1-8 alkyl) -C (O) -NHSO2- C1-8 alkyl, -N (C1-8 alkyl) -C (O ) -N (C1-8alkyl) -SO2- C1-8alkyl, -S- C1-8alkyl, - S (O) - C1-8alkyl, -SO2- C1-8alkyl, -S-aryl, - S (O) -aryl, SO2-aryl, -SO2NH2, -SO2NH- (C1-8alkyl), -SO2N (C1-8alkyl) 2; -aryl, - (C1-4-alkyl) -aryl, heteroaryl or - (C1-4-alkyl) -heteroaryl, in which the aryl ring contains 6 to 14 carbon atoms, and the heteroaryl ring contains a ring system 5-14 membered with one to four heteroatoms each independently selected from O, S and N, wherein each of the R3 groups mentioned above may optionally be substituted with an individual group selected from the group consisting of: alkyl C1-4, C1-4 alkoxy, halo C1-4alkyl, -OH, -COOH, -CN, -NO2, halo, - NH2 and -SO2NH2. |
| priorityDate | 2011-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 549.