| abstract |
An antibody, or antigen-binding fragment thereof, that binds to human BMP-6 (SEQ ID NO: 1), which comprises a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises the complementarity determining regions (CDR) LCDR1, LCDR2 and LCDR3 and the HCVR comprises the CDR HCDR1, HCDR2 and HCDR3, wherein the LCDR1 is the RSSENIYRNLA polypeptide (SEQ ID NO: 2), the LCDR2 is the AATNLAD polypeptide (SEQ ID NO: 3), LCDR3 is the QGIWGTPLT polypeptide (SEQ ID NO: 4), HCDR1 is the GYTFTSYAMH polypeptide (SEQ ID NO: 5), HCDR2 is the polypeptide of YINPYNDGTKYNENFKG (SEQ ID NO: 6) or YINPYNRGTKYNENFKG (SEQ ID NO: 7) and HCDR3 is the RPFGNAMDI polypeptide (SEQ ID NO: 8). |