| abstract |
Composition for oral administration to an animal comprising a pharmaceutical active ingredient and a pharmaceutically acceptable carrier, wherein the pharmaceutical active ingredient comprises tetra-O-methyl-NDGA, and the carrier comprises polyethylene glycol, a cyclodextrin and optionally at least one of a solubilizing agent and an excipient selected from the group consisting of: (a) a water soluble organic solvent other than DMSO; provided that when the water-soluble organic solvent is propylene glycol, the propylene glycol is in the absence of white petrolatum, in the absence of xanthan gum and in the absence of at least one of glycerin or glycine, when the water-soluble organic solvent is polyethylene glycol, the polyethylene glycol is present in the absence of ascorbic acid or butylated hydroxytoluene, and when the polyethylene glycol is polyethylene glycol 400, the polyethylene glycol 400 is present in the absence of polyethylene glycol 8000; (b) an ionic, nonionic or amphipathic surfactant, provided that when the surfactant is a nonionic surfactant, the nonionic surfactant is present in the absence of xanthan gum; (c) a modified cellulose; (d) a water insoluble lipid, provided that the water insoluble lipid is castor oil, castor oil is present in the absence of beeswax or carnauba wax; and a combination of any of the carriers (a) - (d). |