abstract |
A double-stranded, lipid-modified RNA, comprising a sense chain that has a nucleotide sequence complementary to a target sequence in a target gene, and an antisense chain that has a nucleotide sequence complementary to the sense chain, the sense chain being capable of Double stranded RNA suppresses the expression of the target gene, and the strand having a double stranded lipid directly or through a linker having at least one of the first to sixth nucleotides from the 5 'end, where the lipid of Double chain is phosphatidylethanolamine. |