| abstract |
A compound of Formula (Id) or a pharmaceutically acceptable salt thereof: ** Formula ** in which: Z2 is -N- or CR2 in which R2 is hydrogen or alkyl; ** Formula ** is a ring of formula ** Formula ** R6 and R7 are independently hydrogen, methyl, methoxy, fluorine, chlorine, trifluoromethyl, trifluoromethoxy, or cyano; -Z-EWG- is - (alkylene) -NR'CO-, - (alkylene) -NR'SO2-, ** Formula ** Each ring is optionally substituted with one or two substituents independently selected from alkyl, hydroxy, or halo and the carbonyl and sulfonyl groups in - (alkylene) -NR'CO-, - (alkylene) -NR'SO2-, ** Formula ** is bound to -C (CN)> = CHRc; and each R 'is independently hydrogen or alkyl; and Rc is alkyl, haloalkoxy, substituted alkyl, cycloalkyl, cycloalkyleneNRdRe or cycloalkylene (alkylene) NRdRe (in which Rd and Re are independently hydrogen, alkyl, or cycloalkyl), or 3 to 6 membered saturated monocyclic heterocyclyl containing one or two heteroatoms selected from N, O, or S and optionally substituted with one or two substituents selected from hydroxy, alkyl or fluorine. |