abstract |
Conveyor construct comprising or consisting of at least one D / L standard of the generic formula (i): ** Formula ** where D is a D-amino acid; L is an L-amino acid; a is 0-3; i, m and n are, independently of each other, 1 or 2; x and y are, independently of each other, 0, 1 or 2; in particular the transported construct comprising less a D / L pattern according to one of the following sub-formulas (ia) to (if): (Ia): DlLLLxDm; (Ib): DlLLLxDmLLLyDn; (Ic): DlLLLxDmLLLyDnLLLyDn; (Id): DlLLLxDmLLLyDnLLLyDnLLLyDn; (Ie): DLLLD (LLLD) a, or (If): DLLLDLLLD, and applying the D / L pattern according to the generic formula (I) or according to any of the sub-formulas (Ia), (Ib), ( Ic), (Id), (Ie) or (If) to one of the following sequences: ** Table ** or an inverse sequence of these, or a variant or fragment of these sequences, retaining a variant or fragment of these sequences the function of enabling a translocation through biological membranes and consisting of a peptide sequence that has a sequence identity of at least 80% over the entire length in relation to the respective native sequence. |