| abstract |
A bispecific antibody that specifically binds to the two targets that are the extracellular domain of the human B cell maturation antigen (also called "BCMA") and CD3ε (also called "CD3"), which is characterized by comprising aa) the first light chain and the first heavy chain of a first antibody that specifically binds to BCMA; b) the second light chain and the second heavy chain of a second antibody that specifically binds to CD3, and wherein the variable domains VL and VH in the second light chain and in the second heavy chain of the second antibody are substituted for each other. ; and wherein c) in the constant CL domain of the first light chain in a) the amino acid at position 124 is independently substituted by lysine (K), arginine (R) or histidine (H) (numbering according to Kabat), and wherein in the constant CH1 domain of the first heavy chain in a) the amino acid at position 147 and the amino acid at position 213 are independently substituted by glutamic acid (E), or aspartic acid (D) (numbering of agreement with Kabat). |