http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2601004-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2011-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_923868fa614771ccf4328869f957f7a2 |
| publicationDate | 2017-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2601004-T3 |
| titleOfInvention | Pirazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| abstract | A compound chosen from the formula I: ** Formula ** and the stereoisomers, geometric isomers, tautomers or pharmaceutically acceptable salts thereof, wherein: R1 is H, C1-C12 alkyl, C2-C8 alkenyl, C2-C8 alkynyl , C6-C20 aryl, C3-C12 carbocyclyl, heterocyclyl of 3 to 20 ring atoms or heteroaryl of 5 to 20 ring atoms; R2 is H, heterocyclyl of 3 to 20 ring atoms, heteroaryl of 5 to 20 ring atoms, - (heteroaryl of 5 to 20 ring atoms) - (heterocyclyl of 3 to 20 ring atoms), aryl C6-C20, C3-C12 carbocyclyl, NR4R5 or OR4; or R1 and R2 together form a heterocyclyl of 3 to 20 ring atoms or a heteroaryl of 5 to 20 ring atoms; X is chosen from the structures: in which the wavy line indicates the site of the junction; R3 is H, Cl, Br, C1-C12 alkyl, - (C1-C12 alkylene) - (C3-C12 carbocyclyl), - (C1-C12 alkylene) - (heterocyclyl of 3 to 20 ring atoms), - ( C2-C8 alkenylene) - (C3-C12 carbocyclyl), - (C2-C8 alkenylene) - (heterocyclyl of 3 to 20 ring atoms), C6-C20 aryl, - (C6-C20 arylene) - (3-heterocyclyl at 20 ring atoms), - (C6-C20 arylene) - (C1-C12 alkylene) - (3 to 20 ring heterocyclyl), C3-C12 carbocyclyl, 3 to 20 ring heterocyclyl or heteroaryl of 5 to 20 ring atoms; R4 and R5 are independently selected from H, C1-C12 alkyl, C6-C20 aryl, C3-C12 carbocyclyl, heterocyclyl of 3 to 20 ring atoms, heteroaryl of 5 to 20 ring atoms, - (C1- alkylene C12) - (C6-C20 aryl), - (C1-C12 alkylene) - (C3-C12 carbocyclyl), - (C1-C12 alkylene) - (heterocyclyl of 3 to 20 ring atoms), - (C1- alkylene C12) - (heteroaryl of 5 to 20 ring atoms); or R4 and R5 together form a heterocyclyl of 3 to 20 ring atoms or a heteroaryl of 5 to 20 ring atoms; R6 is H or -NH2; R7 is H, F, CH2F, CHF2 and CF3; and said alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl and heteroaryl are optionally substituted by one or more groups independently selected from F, Cl, Br, I, -CH3, -CH2CH3, -CH (CH3) 2, -CH2CH (CH3) 2, -CH2NH2, -CH2CH2NH2, -CH2CHCH2NH2, -CH2CH (CH3) NH2, -CH2OH, -CH2CH2OH, -C (CH3) 2OH, -CH (OH) CH (CH3) 2, -C ( CH3) 2CH2OH, -CH2CH2SO2CH3, -CN, -CF3, -CO2H, -COCH3, -CO2CH3, -CO2C (CH3) 3, -COCH (OH) CH3, -CONH2, -CONHCH3, -CON (CH3) 2, - C (CH3) 2CONH2, -NO2, -NH2, -NHCH3, -N (CH3) 2, -NHCOCH3, -N (CH3) COCH3, -NHS (O) 2CH3, -N (CH3) C (CH3) 2CONH2, -N (CH3) CH2CH2S (O) 2CH3,> = O, -OH, -OCH3, -S (O) 2N (CH3) 2, -SCH3, -CH2OCH3, -S (O) 2CH3, cyclopropyl, cyclobutyl, cyclopentyl , cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl) ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl and morpholino, provided that the compound of the formula (I) is not ** Formula ** |
| priorityDate | 2010-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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