| abstract |
A compound of general formula (I), ** Formula **, tautomeric forms, stereoisomers, polymorphs, solvates, and pharmaceutically acceptable salts and compositions thereof, wherein A represents a substituted or unsubstituted phenyl group; B represents substituted or unsubstituted phenyl; X represents a carbon atom; - R represents substituted or unsubstituted groups selected from aryl; heteroaryl, the heteroaryl groups being selected from pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, thiadiazolyl, tetrazolyl, pyrimidinyl, pyrazine, benzofuranyl, benzoimidazolyl and benzothiazolyl; -OSO2R ', where R' is selected from substituted or unsubstituted alkyl, aryl, alkyldialkylamino, haloalkyl, heterocyclyl and heteroaryl groups; or R is a substituted or unsubstituted heterocyclyl group chosen from morpholine, piperazine, piperidine, pyrrolidine and thiazolidine, the heterocyclyl group being optionally substituted with substituents independently selected from substituted or unsubstituted heteroaryl, alkylaryl (-CH2-Aryl), alkylheteroaryl (- CH2-Heteroaryl), substituted heteroarylcarbonyl (-CO-Heteroaryl), cyanoalkyl, alkylsulfonyl, haloalkylsulfonyl, formyl and other substituted or unsubstituted heterocyclyl group; the binding of the heterocyclyl group to the pyrimidine ring being through carbon or nitrogen; - R1 represents hydrogen, hydroxy, nitro, azido, substituted or unsubstituted halogens groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl , sulfamoyl, -SO2NHNH2 -SO2Cl and carboxylic acid; - R2 represents hydrogen, hydroxy, nitro, azido, substituted or unsubstituted halogens groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl , sulfamoyl, -SO2NHNH2, -SO2Cl and carboxylic acid - R3 represents hydrogen, hydroxy, nitro, azido, substituted or unsubstituted halogens selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, -SO2NHNH2, -SO2Cl and carboxylic acid; - R4 represents hydrogen, hydroxy, nitro, azido, substituted or unsubstituted halogens groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl , sulfamoyl, -SO2NHNH2, -SO2Cl and carboxylic acid; and when the groups R, R1, R2, R3, R4 and R 'are substituted with one or more substituents, these substituents are selected from halogens, hydroxy, nitro, cyano, ureas, azido, amino, imino-1-phenylbutanone, amide , thioamide, hydrazine, alkyl, alkoxy, haloalkyl, haloalkoxy, cycloalkyl, aryloxy, acyl groups comprising acetyl and benzoyl, haloacyl, acyloxyacyl, heterocyclyl, aryl, heteroaryl, monoalkylamino, dialkylamino, acylamino, alkoxycarbonyl groups, methoxycarbonyl, methoxycarbonyl and methoxycarbonyl groups , alkylsulfonyl, haloalkylsulfonyl, arylsulfonyl, alkylsulfinyl, arylsulfinyl, thioalkyl, thioaryl, sulfamoyl, alkoxyalkyl groups, carboxylic acids and their derivatives comprising hydroxamic acid, hydroxamates, esters, amides and acid halides; these substituents being optionally further substituted with substituents selected from hydroxy, alkoxy, halogens, haloalkyl, alkyl and aryl which in turn is optionally further substituted with groups comprising halogens and alkyl. |