| abstract |
Compound, or pharmaceutically acceptable salt thereof, having a structure represented by a formula: ** Formula ** wherein A is CR2 or N; where L is O; where W is CR6 or N; where Z is CR6a or N; provided that only one of W and Z is N; wherein R1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; wherein R1 is substituted with 0-3 of R9; wherein R2 is hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, amino, hydroxyl, alkylamino, dialkylamino, NO2, CN, SO2R8 or COR8; wherein R3 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl and CN; wherein R4 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy and C1-C6 haloalkoxy, hydroxyl, amino, alkylamino, dialkylamino, CN, SO2R8 and COR8; wherein R5 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, CN, SO2R8 and COR8; wherein R6, when present, is selected from hydrogen, halogen, CN, C3-C4 cycloalkyl, C3-C4 halocycloalkyl, C1-C6 alkyl, and C1-C6 haloalkyl; wherein R6a, when present, is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy and C1-C6 haloalkoxy; wherein R6b is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, and C1-C6 haloalkoxy; wherein R6c is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, and C1-C6 haloalkoxy; wherein R8 is C1-C6 alkyl, C1-C6 cycloalkyl, amino, alkylamino, or dialkylamino; and wherein each R9, when present, is independently halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C4 cycloalkyl, C3-C4 halocycloalkyl, C1-C6 haloalkoxy, hydroxyl, amino, alkylamino. , dialkylamino, NO2, CN, SO2R8 or COR8. |