| abstract |
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof in which: R1 represents 1H-benzimidazolyl or ** Formula ** in the A represents an unbranched or branched C1-6 alkylene chain; and R11, R12 and R13 independently represent H or C1-2 alkyl; R2 represents aryl, heteroaryl, phenyl substituted phenyl, phenyl condensed with heterocyclyl or R2 and R3 are joined to form a carbocyclyl ring that is fused to phenyl; the aryl, heteroaryl, phenyl, heterocyclyl and carbocyclyl mentioned above being optionally substituted with one or more groups selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 thioalkyl, -SOalkyl C1-4, -SO2 C1-4 alkyl, C1-6 alkoxy, -O3-8 cycloalkyl, C3-8 cycloalkyl, -SO2 C3-8 cycloalkyl, -C3-6 cycloalkyl, C3-6 alkenyloxy, C3- alkyloxy 6-, -C (O) C1-6 alkyl, -C (O) C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, nitro, halogen, cyano, hydroxyl, -C (O) OH, - NH2, -N C1-4alkyl, -N (C1-4alkyl) (C1-4alkyl), -C (O) N (C1-4alkyl) (C1-4alkyl), -C (O) NH2, - C (O) NH (C1-4 alkyl) and -C (O) NH (C3-10 cycloalkyl); R3 represents H or R2 and R3 are joined to form a carbocyclyl ring that is fused to phenyl; R4 represents H; X represents O or S; and Y represents O or S. |