http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2598877-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcce39a20bef16c3f04497659caba40f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate | 2012-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2017-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c56159e80f5bc4cd942a7b810bd84d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_886e43dbe4115a6e14f3056149822668 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0afd346cbf96f8c9c561fd8e204c6f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64b6eb1d5a3f8b699c241a8d9da861b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_716166df2ee90110dd7d454c932b41f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a03e05c8948cf07c898c46bef35a811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d99c9e788cd4084b1a73d4accf2fd22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50b7143728a9140c4bbb700b4b8fdd5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af724e4be201e488977b185966e84d54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67724fb6ccf53b6ad8eccce3b97eac4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063dd3899d19d46f6f96f6177491c7be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d517ef1240b88885dc2dc420c6e6966c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7623e4677b02494cc1bb99dba1103052 |
publicationDate | 2017-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2598877-T3 |
titleOfInvention | Derivatives of 8-carbamoyl-2- (pyrid-6-yl 2,3-disubstituted) -1,2,3,4-tetrahydroisoquinoline as inducing agents for apoptosis for the treatment of cancer and immune and autoimmune diseases |
abstract | A compound having Formula (I) ** Formula ** or a therapeutically acceptable salt thereof, wherein X is benzo [d] thiazolyl, thiazolo [5,4-b] pyridinyl, thiazolo [4,5-c] pyridinyl, imidazo [1,2-a] pyridinyl, thiazolo [5,4- c] pyridinyl, thiazolo [4,5-b] pyridinyl, imidazo [1,2-a] pyrazinyl, or imidazo [1,2-b ] pyridazinyl; Y1 is pyrrolyl, pyrazolyl, triazolyl or pyridinyl; wherein Y1 is optionally substituted with one, or two substituents independently selected from the group consisting of R5, CN, F, Cl, Br and I; L1 is selected from the group consisting of (CR6R7) q, (CR6R7) s-LOC6R7) r, (CR6R7) sS- (CR6R7) r, (CR6R7) s-SO) 2- (CR6R7) r, (CR6R7) s -NR6AC (O) - (CR6R7) r, (CR6R7) sC (O) NR6A- (CR6R7) r, (CR6R7) s-NR6A- (CR6R7) ry (CR6R7) s- SO) 2NR6A- (CR6R7) r; Y2 is C8-C14 cycloalkyl or C8-C14 heterocycloalkyl; wherein Y2 is optionally substituted with one, two, or three substituents independently selected from the group consisting of R8, O8, SO2R8, CO (O) R8, OH, F, Cl, Br and I; Z1 is selected from the group consisting of ** Formula ** R1 is absent: R2, in each case, is independently deuterium or C1-C6 alkyl; R3 is absent; R5, in each case, is independently C1-C6 alkyl; R6A is independently selected from the group consisting of hydrogen and C1-C6 alkyl; R6 and R7, in each case, are each independently hydrogen; R8, in each case, is independently selected from the group consisting of C1-C6 alkyl, heterocyclyl and cycloalkyl; wherein R8 C1-C6 alkyl is optionally substituted with a substituent independently selected from the group consisting of R16, O16, SO2R16, and NHR16; Rk, in each case, is independently selected from the group consisting of C1-C6 alkyl, C3-C7 heterocycloalkyl, C3-C7 cycloalkyl and C1-C6 haloalkyl; R16, in each case, is independently selected from the group consisting of C1-C4 alkyl, phenyl, and heterocycloalkyl; wherein R16 C1-C4 alkyl is optionally substituted with a substituent independently selected from the group consisting of OCH3, OCH2CH2OCH3 and OCH2CH2NHCH3; q is 1 or 2; s is 0 or 1; r is 0 or 1; in which the sum of s and r is 0 or 1; m is 0: n is 0, 1, or 2; and p is 0. |
priorityDate | 2011-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1433.