| abstract |
A compound represented by the following structural formula: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: X is N or CRc; R1 is alkyl or -NRaRb; R2 is H; halogen; -CN; -NRC (O) R; -C (O) OR; -C (O) NRaRb; monocyclic heteroaromatic optionally substituted with one or more groups selected from alkyl, -CN, -NRC (O) R, -C (O) OR, -C (O) NRaRb and halogen; monocyclic non-aromatic heterocycle optionally substituted with one or more groups selected from alkyl, halogen, -CN and> = O; or alkyl optionally substituted with one or more groups selected from halogen, hydroxy, alkoxy, -NRaRb, -NRC (O) R, -NRC (O) O (alkyl), -NRC (O) N (R) 2, -C (O) OR, thiol, alkylthiol, nitro, -CN,> = O, -OC (O) H, -OC (O) (alkyl), -OC (O) O (alkyl), -OC (O) N (R) 2 and -C (O) NRaRb; R3 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, monocyclic non-aromatic heterocycle, monocyclic heteroaromatic or phenyl, wherein the phenyl, the monocyclic non-aromatic heterocycle and the monocyclic heteroaromatic group represented by R3 are optionally substituted with one or more groups selected from alkyl, halogen, haloalkyl, alkoxy, haloalkoxy, nitro and -CN; R4 is halogen, -CN, -OR, -SR, -N (R) 2, -C (O) R, -C (O) OR, -OC (O) O (alkyl), -C (O) O (haloalkyl), -OC (O) R, -C (O) N (R) 2, -OC (O) N (R) 2, -NRC (O) R, -NRC (O) O (alkyl), -S (O) R, -SO2R, -SO2N (R) 2, -NRS (O) R, -NRSO2R, -NRC (O) N (R) 2, -NRSO2N (R) 2, haloalkyl, haloalkoxy, cycloalkoxy , cycloalkyl, monocyclic non-aromatic heterocycle, monocyclic heteroaromatic or alkyl, wherein the monocyclic non-aromatic heterocycle, the monocyclic heteroaromatic and the alkyl group represented by R4 are optionally substituted with one or more groups selected from -CN, -OR, -SR, -N (R) 2,> = O, -C (O) R, -C (O) OR, -C (O) O (haloalkyl), -OC (O) R, -OC (O) O (alkyl ), -C (O) N (R) 2, -OC (O) N (R) 2, -NRC (O) R, -NRC (O) O (alkyl), -S (O) R, -SO2R , -SO2N (R) 2, -NRS (O) R, -NRSO2R, -NRC (O) N (R) 2 and -NRSO2N (R) 2; Each R is independently H or alkyl; Ra and Rb are independently H, alkyl or Ra and Rb can be taken together with the nitrogen to which they are attached to form a monocyclic non-aromatic heterocycle; and Rc is H, alkyl, or halogen. |