| abstract |
A fusion protein, which is obtained by fusion of a peptide hormone with a transport protein through a linker, where the peptide hormone is exendin-4 or the analog of exendin-4, and the peptide hormone is capable of lowering blood glucose; the transport protein is the Fc fragment of the IgG2 immunoglobulin; the fusion protein is capable of lowering blood glucose; the exendin-4 analog is a peptide that has 6 or less differences of amino acid sites with SEQ ID No. 1; The linker is a peptide having the sequence shown by (Gly) mXaa- (Gly) n, in which, m is an integer between 3 and 8, n is an integer between 3 and 8, Xaa is one anyone selected in the group consisting of Gly, Ser, Ala and Thr. |