| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7dfb0281008cb570feea037cd350c8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbdae384a9f1ad0588422c89ddc71a00 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21022 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-644
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4846
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J7-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2010-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c06b836c3f3879488b9f88ee33f86d54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e15f1dcddfbcb60d081b0a4778dcc90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32e910f8e232b19faa7675806a88daf3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f994e11f3509b1dcbb9f905de3d6297 |
| publicationDate |
2017-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2597954-T3 |
| titleOfInvention |
Blood coagulation protein conjugates |
| abstract |
A method of conjugating a polysalic acid (PSA), which contains an active aminooxy group, to an oxidized carbohydrate moiety of a blood coagulation protein, which comprises contacting the oxidized carbohydrate moiety with an activated PSA under conditions that allow conjugation; wherein said blood coagulation protein has biological activity of Factor IX (FIX) or biological activity of Factor VIII (FVIII); wherein said carbohydrate moiety is oxidized through incubation with a buffer comprising an oxidizing agent selected from the group consisting of sodium periodate (NalO4), lead tetraacetate (Pb (OAc) 4) and potassium perrutenate (KRuO4); and that an oxime bond is formed between the oxidized carbohydrate moiety and the active aminooxy group in the PSA. |
| priorityDate |
2009-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |