| abstract |
A bicycloheteroaryl compound according to formula II, III or IV: ** Formula ** wherein W, Z are CH; L1 is a bond, SO, SO2, or substituted or unsubstituted C1-C5 alkylene; R1 is selected from a substituted or unsubstituted aryl; R 2 and R 2 "are each independently selected from hydrogen, halo, and substituted or unsubstituted C 1 -C 6 alkyl; or any of R 2 'and R 2" join to form a 3-7 atom cycloalkyl or cycloheteroalkyl ring; R3 is selected from hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted bicycloaryl, and substituted or unsubstituted bicycloheteroaryl, - OH, -NH2 and -NH-R59a, and wherein R59a is alkyl, cycloalkyl, acyl, aryl or heteroaryl; R5 is independently selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, substituted or alkoxycarbonyl, substituted or unsubstituted alkylarylamino. substitute, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, ester sulfuric acid, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted amino-dihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, halo or heteroaryloxy, heteroaryl its substituted or unsubstituted, substituted or unsubstituted heteroalkyl, hydroxy, nitro and thio; or a pharmaceutically acceptable salt or solvate thereof; and stereoisomers, isotopic variants, and tautomers thereof. |