| abstract |
A compound that has a structure according to Formula (II): ** Formula ** where m is an integer from 0 to 12, which is not greater than 10 Ar is ** Formula ** where Y and Z are each independently halogen; or Ar is ** Formula ** wherein Y1, Z1, Y2, Z2 and are members independently selected from the group consisting of: H, halogen, CN, CF3, OMe, OEt and OCF3; each X is a member independently selected from the group consisting of H, halogen, CN, CF3, OR5, SR5, acyl, C (O) OR5, C (O) NR6R7, S (O) 2R5, S (O) 2NR6R7, NR6R7, NR6S (O) 2R5, NR6C (O) R5, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl, wherein each R5, R6 and R7 is a member independently selected from the group consisting of H, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl, wherein two of R5, R6 and R7, together with the atoms to which they are attached, they optionally bind to form a 3 to 7 member ring; each R1 and R2 is a member independently selected from the group consisting of H and (C1-C4) substituted or unsubstituted alkyl; R3 and R4 are members independently selected from the group consisting of H, substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl; with the proviso that the compound is not: ** Formula ** and any salt, enantiomer, diastereomer, racemic mixture, enantiomerically enriched mixture, and pharmaceutically acceptable enantiomerically pure form thereof; wherein the substituents for the alkyl, heteroalkyl and heterocycloalkyl radicals are selected from the group consisting of: unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted aryl, unsubstituted heteroaryl, unsubstituted heterocycloalkyl-OR ',> = O,> = NR '> = N-OR', -NR'R ", - SR ', -halogen, -SiR'R" R "', -OC (O) R ', -C (O) R', - CO2R ', -CONR'R ", -OC (O) NR'R", - NR "C (O) R ', -NR'-C (O) NR" R "', -NR" C (O) 2R ', -NR-C (NR'R "R" ')> = NR "", - NRC (NR'R ")> = NR"', -S (O) R ', -S (O) 2R', - S (O) 2NR'R ", -NRSO2R ', -CN and -NO2 in a number that varies from zero to (2m' + 1), where m 'is the total number of carbon atoms in such a radical; R ', R ", R'" and R "" each independently refer to hydrogen, unsubstituted heteroalkyl, unsubstituted aryl, unsubstituted alkyl, alkoxy or thioalkoxy groups, or arylalkyl groups; and wherein the substituents for the aryl and heteroaryl groups are selected from the group consisting of: unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted aryl, unsubstituted heteroaryl, unsubstituted heterocycloalkyl, - OR ',> = O,> = NR '> = N-OR', -NR'R ", -SR ', -halogen, -SiR'R" R "', -OC (O) R ', -C (O) R', -CO2R ' , -CONR'R ", - OC (O) NR'R", - NR "C (O) R ', -NR'-C (O) NR" R "', -NR" C (O) 2R ' , -NR-C (NR'R "R" ')> = NR "", -NR-C (NR'R ")> = NR"', - S (O) R ', - S (O) 2R ', -S (O) 2NR'R ", -NRSO2R', -CN, -NO2, -R ', -N3, -CH (Ph) 2, fluoro (C1-C4) alkoxy, and fluoro (C1- C4 ) alkyl, in a number ranging from zero to the total number of open valences in the aromatic ring system; and where R ', R ", R'" and R "" are each independently selected from hydrogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted aryl and unsubstituted heteroaryl. |