| abstract |
The process for obtaining 3,3-diphenylpropylamines (I), where R1 is H, alkyl, haloalkyl or alkoxyalkyl, R2 is alkyl, alkoxy, halogen, NO2, CN, CHO free or protected, CH2OH or COOR6, and R3 and R4, independently, are selected from H and alkyl or together form a 3-7 membered ring with the nitrogenal to which they are attached, comprises reacting a propylene phenylamine and a disubstituted aromatic hydrocarbon and, if desired, separating the desired enantiomer, or the mixture of enantiomers, and / or converting compound (I) to a salt. Compounds (I) are muscarinic receptor antagonists, useful in the treatment of urinary incontinence and other symptoms of hyperactivity of the urinary bladder. Among these compounds is latolterodine. |