http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2590917-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate | 2009-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_689aab58e11274b992bd64a96a660086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b98eb6a466fd4271d3dab4d9badc4b04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33847004584372a0068499425f39b15e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4acb07b47ee767806a0f90ef8b59c0b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e710223adc9824e9ad8d19fc8985e24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fba81a5582ad9cce287ce596442f685 |
| publicationDate | 2016-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2590917-T3 |
| titleOfInvention | Heteroaryl substituted dicianopyridines and their use for the treatment of cardiovascular diseases |
| abstract | Compound of Formula (I) ** Formula ** in which X represents O or S, R1 represents 5- or 6-membered heteroaryl, with 5- or 6-membered heteroaryl being substituted with 1 or 2 substituents selected, independently of one another, from the group halogen, nitro, cyano, (C1-C6) alkyl, trifluoromethyl, hydroxy, (C1-C6) alkoxy, amino, mono-(C1-C6) -alkyl-amino, di-(C1-C6) -alkyl-amino , hydroxycarbonyl, alkoxy- (C1-C6) -carbonyl, aminocarbonyl, mono-alkyl- (C1-C6) -aminocarbonyl, di-C1- C6-alkylcarbonyl, cycloalkyl- (C3-C7) -aminocarbonyl, aminosulfonyl , mono-(C1-C6) -alkyl-amino-sulfonyl, di-(C1-C6) -alkyl-amino-sulfonyl, alkyl- (C1-C6) -sulfonylamino, pyrrolidino, piperidino, morpholino, piperazino, N'-alkyl- (C1 -C4) -piperazino, pyrrolidinocarbonyl, piperidinocarbonyl, morpholinocarbonyl, piperazinocarbonyl, N'-C1-C4-alkyl-, phenyl and 5- or 6-membered heteroaryl, wherein 5 or 6 membered phenyl and heteroaryl can be substituted with 1 to 3 substitute Independently selected from the group of halogen, nitro, cyano, (C1-C6) alkyl, difluoromethyl, trifluoromethyl, hydroxy, (C1-C6) alkoxy, difluoromethoxy, trifluoromethoxy, amino, mono-alkyl- (C1-C6). ) -amino, di-(C1-C6) -alkyl-amino, hydroxycarbonyl and alkoxy- (C1-C6) -carbonyl, R2 represents hydrogen or (C1-C4) alkyl, R3 represents thienyl, pyrrolyl, oxaxolyl, thiazolyl, isoxazolyl , isothiazolyl, pyrazolyl, imidazolyl, triazolyl, oxadiazolyl, thiadiazolyl, or tetrazolyl, with thienyl, pyrrolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, pyrazolyl, imidazolyl, triazolyl, oxadiazolyl, thiadiazolyl, and tetrazolyl being independently substituted. yes, from the group of halogen, cyano, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C7) cycloalkoxy and -NRARB, where (C1-C6) alkyl and (C1-C6) alkoxy they can be substituted with 1 to 3 substituents selected, independently of each other, from the group or of fluorine, trifluoromethyl, (C3-C7) cycloalkyl, oxo, hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, amino, mono-C1- C4-alkyl-amino and di-C1- C4-alkyl- amino and wherein (C3-C7) cycloalkoxy can be substituted with 1 or 2 substituents selected, independently of each other, from the group of (C1-C4) alkyl, hydroxy, oxo and (C1-C4) alkoxy and where RA represents hydrogen or (C1-C6) alkyl, in which, in turn, (C1-C6) alkyl can be substituted with 1 to 3 fluoro substituents and in which, in turn, (C1-C6) alkyl can be substituted with a substituent selected from the group of hydroxy and (C1-C4) alkoxy, RB represents hydrogen, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) -alkylcarbonyl, (C1-C4) -alkyl - sulfonyl or cycloalkyl- (C3-C7) -sulfonyl, in turn, (C1-C6) alkyl may be substituted with 1 to 3 fluorine substituents and may, in turn, be substituted (C1-C6) alkyl with 1 or 2 substituents selected, independently of each other, from the cycloal group (C3-C7) chyl, oxo, hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, amino, mono-C1- C4-alkyl-amino, di-C1- C4-amino and cycloalkyl- (C3) -C7) -amino and may, in turn, be substituted (C3-C7) cycloalkyl with 1 or 2 substituents selected, independently of each other, from the group of (C1-C4) alkyl, hydroxy, oxo and (C1-C4) alkoxy ) or RA and RB together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle which may contain an additional N, O or S series ring hetero atom and may be substituted with 1 or 2 selected substituents, independently of each other, from the group (C1-C4) -alkyl, hydroxy, oxo and (C1-C4) -alkoxy, R4 represents hydrogen or (C1-C6) -alkyl, and C1-C6-alkyl may be substituted with 1 or 2 selected substituents , independently of each other, from the group of hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, (C1-C4) alkoxycarbonyl, amino, mono-(C1-C4) -alkyl-amino and di-(C1-C4) -alkyl- amino, R5 represents hydrogen or alkyl or (C1-C6), (C1-C6) alkyl may be substituted with 1 or 2 substituents selected, independently of each other, from the group of hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, alkoxy- (C1-C4) -carbonyl , amino, mono-(C1-C4) -alkyl-amino and di-(C1-C4) -alkyl-amino, R4 and R5 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle that can contain an additional ring hetero atom of the N, O or S series and may be substituted with 1 or 2 substituents selected, independently of one another, from the group of (C1-C4) alkyl, hydroxy, oxo and (C1-C4) alkoxy, as well as their N-oxides, salts, solvates, salts of N-oxides and solvates of N-oxides and salts. |
| priorityDate | 2008-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1032.